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    Prrg4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) [ Mus musculus (house mouse) ]

    Gene ID: 228413, updated on 9-May-2024

    Summary

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    Official Symbol
    Prrg4provided by MGI
    Official Full Name
    proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)provided by MGI
    Primary source
    MGI:MGI:2442211
    See related
    Ensembl:ENSMUSG00000027171 AllianceGenome:MGI:2442211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TMG4; 9930111I18Rik
    Summary
    Predicted to enable WW domain binding activity. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human PRRG4 (proline rich and Gla domain 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 2.9), bladder adult (RPKM 1.7) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prrg4 in Genome Data Viewer
    Location:
    2 E2; 2 54.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (104657374..104680216, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (104830741..104849872, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39898 Neighboring gene TAR DNA binding protein pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7844 Neighboring gene STARR-seq mESC enhancer starr_05298 Neighboring gene STARR-positive B cell enhancer mm9_chr2:104728128-104728428 Neighboring gene coiled-coil domain containing 73 Neighboring gene STARR-positive B cell enhancer mm9_chr2:104828551-104828851 Neighboring gene eukaryotic translation initiation factor 3, subunit M Neighboring gene predicted gene, 38521

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117538

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane gamma-carboxyglutamic acid protein 4
    Names
    proline-rich Gla protein 4
    proline-rich gamma-carboxyglutamic acid protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178695.5 → NP_848810.3  transmembrane gamma-carboxyglutamic acid protein 4 precursor

      See identical proteins and their annotated locations for NP_848810.3

      Status: VALIDATED

      Source sequence(s)
      AK035530, AK038703
      Consensus CDS
      CCDS16493.1
      UniProtKB/Swiss-Prot
      Q8BGN6, Q8BM25
      UniProtKB/TrEMBL
      Q3TLN5, Q4KL73
      Related
      ENSMUSP00000028593.5, ENSMUST00000028593.11
      Conserved Domains (2) summary
      pfam00594
      Location:57 → 97
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
      cl15239
      Location:78 → 178
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      104657374..104680216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250334.2 → XP_030106194.1  transmembrane gamma-carboxyglutamic acid protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8BGN6, Q8BM25
      UniProtKB/TrEMBL
      Q3TLN5, Q4KL73
      Conserved Domains (2) summary
      pfam00594
      Location:57 → 97
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
      cl15239
      Location:78 → 178
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGN6.1 GenPept UniProtKB/Swiss-Prot:Q8BGN6

    Gene LinkOut

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