U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sh3bp5l SH3 binding domain protein 5 like [ Mus musculus (house mouse) ]

    Gene ID: 79566, updated on 12-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sh3bp5lprovided by MGI
    Official Full Name
    SH3 binding domain protein 5 likeprovided by MGI
    Primary source
    MGI:MGI:1933124
    See related
    Ensembl:ENSMUSG00000013646 AllianceGenome:MGI:1933124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1720; 2310074E09Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Predicted to be involved in intracellular signal transduction and negative regulation of protein tyrosine kinase activity. Predicted to be active in cytoplasm. Orthologous to human SH3BP5L (SH3 binding domain protein 5 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 19.0), genital fat pad adult (RPKM 18.5) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sh3bp5l in Genome Data Viewer
    Location:
    11 B1.3; 11 36.19 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58221533..58238554)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58330707..58347728)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39827 Neighboring gene STARR-positive B cell enhancer ABC_E2989 Neighboring gene nuclear encoded tRNA leucine 3 (anticodon CAA) Neighboring gene zinc finger protein 692 Neighboring gene STARR-positive B cell enhancer ABC_E3953 Neighboring gene zinc finger protein 672 Neighboring gene predicted gene, 33660 Neighboring gene LY6/PLAUR domain containing 8

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC7813

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SH3 domain-binding protein 5-like
    Names
    SH3BP-5-like

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161338.2 → NP_001154810.1  SH3 domain-binding protein 5-like isoform 1

      See identical proteins and their annotated locations for NP_001154810.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AI505691, BC094418, BY125606
      Consensus CDS
      CCDS24728.1
      UniProtKB/Swiss-Prot
      Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
      UniProtKB/TrEMBL
      Q80TA2
      Related
      ENSMUSP00000112077.3, ENSMUST00000116376.9
      Conserved Domains (1) summary
      pfam05276
      Location:54 → 282
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    2. NM_001308167.1 → NP_001295096.1  SH3 domain-binding protein 5-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI505691, AK150129, BY125606
      UniProtKB/TrEMBL
      Q80TA2
      Conserved Domains (1) summary
      pfam05276
      Location:54 → 280
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    3. NM_001308168.1 → NP_001295097.1  SH3 domain-binding protein 5-like isoform 1

      See identical proteins and their annotated locations for NP_001295097.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AI505691, AK167203, BC094418, CJ153287
      Consensus CDS
      CCDS24728.1
      UniProtKB/Swiss-Prot
      Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
      UniProtKB/TrEMBL
      Q80TA2
      Conserved Domains (1) summary
      pfam05276
      Location:54 → 282
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    4. NM_024480.5 → NP_077800.3  SH3 domain-binding protein 5-like isoform 1

      See identical proteins and their annotated locations for NP_077800.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AI505691, AK159202, AK167203, BC094418, BY125606
      Consensus CDS
      CCDS24728.1
      UniProtKB/Swiss-Prot
      Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
      UniProtKB/TrEMBL
      Q80TA2
      Related
      ENSMUSP00000072872.7, ENSMUST00000073128.7
      Conserved Domains (1) summary
      pfam05276
      Location:54 → 282
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58221533..58238554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534523.2 → XP_006534586.1  SH3 domain-binding protein 5-like isoform X1

      See identical proteins and their annotated locations for XP_006534586.1

      UniProtKB/Swiss-Prot
      Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
      UniProtKB/TrEMBL
      Q80TA2
      Conserved Domains (1) summary
      pfam05276
      Location:54 → 282
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LH9.1 GenPept UniProtKB/Swiss-Prot:Q99LH9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous