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    Acsf3 acyl-CoA synthetase family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 257633, updated on 9-May-2024

    Summary

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    Official Symbol
    Acsf3provided by MGI
    Official Full Name
    acyl-CoA synthetase family member 3provided by MGI
    Primary source
    MGI:MGI:2182591
    See related
    Ensembl:ENSMUSG00000015016 AllianceGenome:MGI:2182591
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable malonyl-CoA synthetase activity and very long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid biosynthetic process and malonate catabolic process. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 25.7), adrenal adult (RPKM 17.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acsf3 in Genome Data Viewer
    Location:
    8 E1; 8 71.97 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123502209..123544626)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122775470..122817887)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530010L16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125299226-125299409 Neighboring gene predicted gene, 39271 Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene cadherin 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin. Head PE, et al. Sci Transl Med, 2022 May 25. PMID 35613279, Free PMC Article
    2. The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency. Bowman CE, et al. Cell Chem Biol, 2017 Jun 22. PMID 28479296, Free PMC Article
    3. Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. Menendez-Montes I, et al. Dev Cell, 2016 Dec 19. PMID 27997827
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. an essential role for ACSF3 in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism
      Title: The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC37904

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-thiol ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malonyl-CoA synthetase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in malonate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    malonate--CoA ligase ACSF3, mitochondrial
    Names
    acyl-CoA synthetase family member 3, mitochondrial
    NP_659181.2
    XP_006531093.1
    XP_006531095.1
    XP_030099428.1
    XP_030099430.1
    XP_036009945.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144932.4 → NP_659181.2  malonate--CoA ligase ACSF3, mitochondrial precursor

      See identical proteins and their annotated locations for NP_659181.2

      Status: VALIDATED

      Source sequence(s)
      AA104822, AK141579, AK144352, BI135241, BQ177632
      Consensus CDS
      CCDS40505.1
      UniProtKB/Swiss-Prot
      Q3URE1, Q78IW2, Q8VC75
      UniProtKB/TrEMBL
      A0A1D5RMC8
      Related
      ENSMUSP00000015160.6, ENSMUST00000015160.6
      Conserved Domains (1) summary
      cd05941
      Location:55 → 569
      MCS; Malonyl-CoA synthetase (MCS)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      123502209..123544626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243568.1 → XP_030099428.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q3URE1, Q78IW2, Q8VC75
      UniProtKB/TrEMBL
      A0A1D5RMC8
      Conserved Domains (1) summary
      cd05941
      Location:55 → 569
      MCS; Malonyl-CoA synthetase (MCS)

    2. XM_006531030.3 → XP_006531093.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006531093.1

      UniProtKB/Swiss-Prot
      Q3URE1, Q78IW2, Q8VC75
      UniProtKB/TrEMBL
      A0A1D5RMC8
      Related
      ENSMUSP00000148762.2, ENSMUST00000212790.2
      Conserved Domains (1) summary
      cd05941
      Location:55 → 569
      MCS; Malonyl-CoA synthetase (MCS)

    3. XM_006531032.4 → XP_006531095.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006531095.1

      UniProtKB/Swiss-Prot
      Q3URE1, Q78IW2, Q8VC75
      UniProtKB/TrEMBL
      A0A1D5RMC8
      Related
      ENSMUSP00000148725.2, ENSMUST00000212781.2
      Conserved Domains (1) summary
      cd05941
      Location:55 → 569
      MCS; Malonyl-CoA synthetase (MCS)

    4. XM_036154052.1 → XP_036009945.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q3URE1, Q78IW2, Q8VC75
      UniProtKB/TrEMBL
      A0A1D5RMC8
      Conserved Domains (1) summary
      cd05941
      Location:55 → 569
      MCS; Malonyl-CoA synthetase (MCS)

    5. XM_030243570.1 → XP_030099430.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q3URE1, Q78IW2, Q8VC75
      UniProtKB/TrEMBL
      A0A1D5RMC8
      Conserved Domains (1) summary
      cd05941
      Location:55 → 569
      MCS; Malonyl-CoA synthetase (MCS)

    RNA

    1. XR_003947284.1 RNA Sequence

    2. XR_003947283.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3URE1.2 GenPept UniProtKB/Swiss-Prot:Q3URE1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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