Zfp593 zinc finger protein 593 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp593provided by MGI
Official Full Name: zinc finger protein 593provided by MGI
Primary source: MGI:MGI:1915290
See related: Ensembl:ENSMUSG00000028840 AllianceGenome:MGI:1915290
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZNF593; 3110024A21Rik; E130106C14Rik
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and submandibular gland primordium. Orthologous to human ZNF593 (zinc finger protein 593). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 7.1), ovary adult (RPKM 6.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.5 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133970617..133972902, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (134243306..134245591, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zfp593 overexpression in cultured muscle cells resulted in significant repression of muscle cell differentiation and attenuation of ERK1/2 and p38 phosphorylation, but did not vitiate protein synthesis. The discovery that Zfp593 is expressed in skeletal muscle combined with the observation that it is induced in response to neurogenic atrophy furthers our understanding of the molecular genetic events of muscle wasting.
Title: Zinc finger protein 593 is upregulated during skeletal muscle atrophy and modulates muscle cell differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables preribosome binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 593

Names: zinc finger protein T86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024215.2 → NP_077177.2 zinc finger protein 593

See identical proteins and their annotated locations for NP_077177.2

Status: VALIDATED

Source sequence(s)

AK005247, AK014081, CO040973

Consensus CDS

CCDS51325.1

UniProtKB/Swiss-Prot

Q3UZX2, Q99J54, Q9DB42

UniProtKB/TrEMBL

Q3U0F2

Related

ENSMUSP00000030644.8, ENSMUST00000030644.8

Conserved Domains (2) summary

COG5112
Location:1 → 108

UFD2; U1-like Zn-finger-containing protein [General function prediction only]

sd00020
Location:63 → 85

ZF_C2H2; C2H2 Zn finger [structural motif]