Nme7 NME/NM23 family member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nme7provided by RGD
Official Full Name: NME/NM23 family member 7provided by RGD
Primary source: RGD:619880
See related: Ensembl:ENSRNOG00000002898 AllianceGenome:RGD:619880
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nm23-r7; nm23-H7
Summary: Predicted to enable ATP binding activity; metal ion binding activity; and nucleoside diphosphate kinase activity. Predicted to be involved in nucleotide metabolic process. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; ciliary receptor clustering involved in smoothened signaling pathway; and intraciliary transport. Predicted to be located in ciliary basal body. Predicted to be active in centrosome. Orthologous to human NME7 (NME/NM23 family member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 432.3), Brain (RPKM 235.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q23

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (79190462..79319890)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (76657303..76786768)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (82607844..82737383)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heterozygous Nme7 Mutation Affects Glucose Tolerance in Male Rats.
Title: Heterozygous Nme7 Mutation Affects Glucose Tolerance in Male Rats.
Semi-Lethal Primary Ciliary Dyskinesia in Rats Lacking the Nme7 Gene.
Title: Semi-Lethal Primary Ciliary Dyskinesia in Rats Lacking the Nme7 Gene.
ln a rat model of metabolic syndrome, expression of Nme7 may have relevance for carbohydrate and lipid metabolism as well as ciliogenesis.
Title: Expression profiling of Nme7 interactome in experimental models of metabolic syndrome.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intraciliary transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within left/right pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule nucleation	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axonemal A tubule inner sheath	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	IEA Inferred from Electronic Annotation more info
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin ring complex	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin ring complex	ISO Inferred from Sequence Orthology more info
part_of gamma-tubulin ring complex	ISS Inferred from Sequence or Structural Similarity more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoside diphosphate kinase homolog 7; nucleoside diphosphate kinase 7

Names: 3'-5' exonuclease NME7; NDK 7; NDP kinase 7; NDP kinase homolog 7; non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase); protein kinase NME7

NP_612541.1

EC 2.7.4.6

XP_063128080.1

EC 2.7.4.6

XP_063128081.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138532.1 → NP_612541.1 nucleoside diphosphate kinase homolog 7

See identical proteins and their annotated locations for NP_612541.1

Status: PROVISIONAL

Source sequence(s)

AF202049

UniProtKB/Swiss-Prot

A6IDE2, Q6PAG9, Q9QXL7

Conserved Domains (4) summary

smart00676
Location:22 → 110

DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases

smart00562
Location:111 → 244

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04412
Location:257 → 390

NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cd04415
Location:111 → 241

NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...