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    Fli1 Fli-1 proto-oncogene, ETS transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315532, updated on 3-Apr-2024

    Summary

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    Symbol
    Fli1provided by RGD
    Full Name
    Fli-1 proto-oncogene, ETS transcription factorprovided by RGD
    Primary source
    RGD:1309837
    See related
    Ensembl:ENSRNOG00000008904 AllianceGenome:RGD:1309837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including blood circulation; megakaryocyte development; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 176.7), Thymus (RPKM 161.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fli1 in Genome Data Viewer
    Location:
    8q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (39089526..39209511, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (30831422..30950468, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (33541932..33661111, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 5 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1 Neighboring gene uncharacterized LOC134479972 Neighboring gene ETS proto-oncogene 1, transcription factor Neighboring gene uncharacterized LOC102552230

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features. Saultier P, et al. Haematologica, 2017 Jun. PMID 28255014, Free PMC Article
    2. Paris-Trousseau thrombocytopenia is phenocopied by the autosomal recessive inheritance of a DNA-binding domain mutation in FLI1. Stevenson WS, et al. Blood, 2015 Oct 22. PMID 26316623
    3. FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia. Raslova H, et al. J Clin Invest, 2004 Jul. PMID 15232614, Free PMC Article
    4. Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes. Nowling TK, et al. Mol Immunol, 2008 Jan. PMID 17606295, Free PMC Article
    5. Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Wei G, et al. Immunity, 2011 Aug 26. PMID 21867929, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blood circulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within megakaryocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Friend leukemia integration 1 transcription factor
    Names
    Friend leukemia integration 1 transcription factor-like
    Friend leukemia virus integration 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017381.2 → NP_001017381.1  Friend leukemia integration 1 transcription factor

      See identical proteins and their annotated locations for NP_001017381.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6ASZ2, F7FFL9, Q4Z8P1
      Related
      ENSRNOP00000059605.1, ENSRNOT00000068037.2
      Conserved Domains (2) summary
      cd08541
      Location:114 → 204
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      smart00413
      Location:280 → 363
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      39089526..39209511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265409.1 → XP_063121479.1  Friend leukemia integration 1 transcription factor isoform X2

    2. XM_063265407.1 → XP_063121477.1  Friend leukemia integration 1 transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3J9

    3. XM_063265408.1 → XP_063121478.1  Friend leukemia integration 1 transcription factor isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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