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    Foxd4 forkhead box D4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252886, updated on 2-May-2024

    Summary

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    Official Symbol
    Foxd4provided by RGD
    Official Full Name
    forkhead box D4provided by RGD
    Primary source
    RGD:621716
    See related
    AllianceGenome:RGD:621716
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HFH-6; FREAC-5
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human FOXD4 (forkhead box D4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See Foxd4 in Genome Data Viewer
    Location:
    1q51
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (231983872..231985565, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (222557494..222559189, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (242808886..242810186, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 252 Neighboring gene phosphoglucomutase 5 Neighboring gene Zn regulated GTPase metalloprotein activator 1A Neighboring gene uncharacterized LOC102556915 Neighboring gene uncharacterized LOC134483982

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FOXD3/FOXD4 is required for the development of hindgut in the rat model of anorectal malformation. Wang LJ, et al. Exp Biol Med (Maywood), 2018 Feb. PMID 29307282, Free PMC Article
    2. Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Clevidence DE, et al. Proc Natl Acad Sci U S A, 1993 May 1. PMID 7683413, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tentative conclusions were drawn that FOXD3/FOXD4 is expressed in the hindgut in rat embryos and is upregulated in anorectal malformation.
      Title: FOXD3/FOXD4 is required for the development of hindgut in the rat model of anorectal malformation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein D4; LOW QUALITY PROTEIN: forkhead box protein D4
    Names
    forkhead-related protein FKHL9
    forkhead-related transcription factor 5
    hepatocyte nuclear factor 3 forkhead homolog 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      231983872..231985565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001055972.6 → XP_001055972.2  LOW QUALITY PROTEIN: forkhead box protein D4

      See identical proteins and their annotated locations for XP_001055972.2

      UniProtKB/TrEMBL
      A0A8I6A8H7
      Conserved Domains (1) summary
      pfam00250
      Location:103 → 189
      Forkhead; Forkhead domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63249.1 GenPept UniProtKB/Swiss-Prot:Q63249

    Gene LinkOut

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