Pth1r parathyroid hormone 1 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pth1rprovided by RGD
Official Full Name: parathyroid hormone 1 receptorprovided by RGD
Primary source: RGD:3442
See related: Ensembl:ENSRNOG00000020948 AllianceGenome:RGD:3442
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pthr; Pthr1; PTHrel
Summary: Enables parathyroid hormone receptor activity and peptide hormone binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of inositol phosphate biosynthetic process. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Part of receptor complex. Used to study hypercalcemia. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 243.9), Liver (RPKM 24.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (119572295..119597405, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (110693910..110725458, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (118984531..119012803, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our study thus demonstrates the new role of PTHrP in fibronectin up-regulation for the first time in glomerular mesangial cells. These data also provided new insights to guide development of therapy for glomerular sclerosis
Title: Parathyroid hormone-related protein induces fibronectin up-regulation in rat mesangial cells through reactive oxygen species/Src/EGFR signaling.
PTHrP (1-40) stimulates calcium uptake via PTHR1 receptor and PKC alpha/beta signaling pathway in rat enterocytes, and calcium transporters TRPV6 and CaBP-D9k are necessary for this stimulatory effect.
Title: Parathyroid Hormone-Related Protein (1-40) Enhances Calcium Uptake in Rat Enterocytes Through PTHR1 Receptor and Protein Kinase Cα/β Signaling.
Results show the expression of PTHrP and its receptor, PTHR1, in the majority of neurons and glial cells in the SCG of rats. Expression of PTHrP, but not PTHR1 in the cytoplasm of SCG neurons is influenced by ovarian activity.
Title: Expression of PTHrP and PTH/PTHrP receptor 1 in the superior cervical ganglia of rats.
Data indicate that PTH1R and PTHrP were more predominantly expressed in smooth muscle than in urothelium.
Title: PTHrP is endogenous relaxant for spontaneous smooth muscle contraction in urinary bladder of female rat.
Vav2 specifically interacted with activated Galpha(q) but not with Galpha(s) subunits, competing with PTHR for coupling to Galpha(q).
Title: The guanine nucleotide exchange factor Vav2 is a negative regulator of parathyroid hormone receptor/Gq signaling.
Nicotine induces PTHrP expression in endothelial cells but excessive concentrations of nicotine reduce PTHrP receptor expression thereby attenuating any protective effects of PTHrP against apoptosis.
Title: Effects of nicotine on PTHrP and PTHrP receptor expression in rat coronary endothelial cells.
Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains
Title: Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains.
This study demonstrates the dynamic expression of EBP50 in vessels following injury and the effects of EBP50 on PTH1R function in vascular smooth muscle cells.
Title: EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells.
These findings suggest that FGFR3 down-regulates PTH/PTHrP receptor gene expression via the JAK/STAT signaling in chondrocytic cells.
Title: FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line.
Downregulation of PTHrP and PTHrP-R gene expression during late lung morphogenesis may cause pulmonary hypoplasia in the nitrofen CDH model, disrupting alveolar maturation and surfactant production by interfering with mesenchymal-epithelial interactions.
Title: Disturbance of parathyroid hormone-related protein signaling in the nitrofen-induced hypoplastic lung.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW532874 (e-PCR)
- UniSTS:260648

UniSTS:498482 (e-PCR)
- UniSTS:498482

Pthr1 (e-PCR), detects polymorphism
- UniSTS:498482

PMC135637P2 (e-PCR)
- UniSTS:270763

UniSTS:498400 (e-PCR)
- UniSTS:498400

Pthr1 (e-PCR), detects polymorphism
- UniSTS:498400

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables parathyroid hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables parathyroid hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables parathyroid hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables parathyroid hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in bone resorption	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone resorption	ISO Inferred from Sequence Orthology more info
involved_in cell maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ossification	ISO Inferred from Sequence Orthology more info
involved_in osteoblast development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoblast development	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IC Inferred by Curator more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: parathyroid hormone/parathyroid hormone-related peptide receptor

Names: PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; parathyroid hormone receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020073.2 → NP_064458.1 parathyroid hormone/parathyroid hormone-related peptide receptor precursor

See identical proteins and their annotated locations for NP_064458.1

Status: PROVISIONAL

Source sequence(s)

L19475

UniProtKB/Swiss-Prot

P25961

UniProtKB/TrEMBL

A6I3G4, A6I3G5

Related

ENSRNOP00000084523.1, ENSRNOT00000100155.1

Conserved Domains (3) summary

pfam02793
Location:105 → 170

HRM; Hormone receptor domain

cd14964
Location:186 → 211

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:184 → 476

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

119572295..119597405 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082024.2 → XP_038937952.2 parathyroid hormone/parathyroid hormone-related peptide receptor isoform X1
XM_006243999.4 → XP_006244061.1 parathyroid hormone/parathyroid hormone-related peptide receptor isoform X2

See identical proteins and their annotated locations for XP_006244061.1

UniProtKB/Swiss-Prot

P25961

UniProtKB/TrEMBL

A6I3G4, A6I3G5

Related

ENSRNOP00000028435.3

Conserved Domains (3) summary

pfam02793
Location:105 → 170

HRM; Hormone receptor domain

cd14964
Location:186 → 211

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:184 → 476

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006244002.4 → XP_006244064.1 parathyroid hormone/parathyroid hormone-related peptide receptor isoform X3

UniProtKB/TrEMBL

A0A8I5ZQF2

Conserved Domains (2) summary

pfam00002
Location:163 → 434

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:84 → 149

HRM; Hormone receptor domain