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    Polr3c polymerase (RNA) III (DNA directed) polypeptide C [ Mus musculus (house mouse) ]

    Gene ID: 74414, updated on 9-May-2024

    Summary

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    Official Symbol
    Polr3cprovided by MGI
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide Cprovided by MGI
    Primary source
    MGI:MGI:1921664
    See related
    Ensembl:ENSMUSG00000028099 AllianceGenome:MGI:1921664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPC3; RPC62; 4933407E01Rik
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to act upstream of or within defense response to virus and innate immune response. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Orthologous to human POLR3C (RNA polymerase III subunit C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 19.8), testis adult (RPKM 14.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Polr3c in Genome Data Viewer
    Location:
    3 F2.1; 3 41.96 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96618836..96634803, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96711520..96727498, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6084 Neighboring gene STARR-seq mESC enhancer starr_08444 Neighboring gene ankyrin repeat domain 35 Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene nudix hydrolase 17 Neighboring gene STARR-positive B cell enhancer ABC_E6085 Neighboring gene predicted gene, 22581 Neighboring gene ring finger protein 115 Neighboring gene CD160 antigen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic variants in an inbred mouse model predict mania-like behaviors. Saul MC, et al. PLoS One, 2018. PMID 29768498, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Spontaneous (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC3
    Names
    DNA-directed RNA polymerase III subunit C
    RNA polymerase III subunit C3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028925.2 → NP_083201.1  DNA-directed RNA polymerase III subunit RPC3

      See identical proteins and their annotated locations for NP_083201.1

      Status: VALIDATED

      Source sequence(s)
      AC112261
      Consensus CDS
      CCDS51010.1
      UniProtKB/Swiss-Prot
      Q8R0I2, Q9D483
      UniProtKB/TrEMBL
      B2RX77
      Related
      ENSMUSP00000029741.3, ENSMUST00000029741.9
      Conserved Domains (2) summary
      pfam05645
      Location:146 → 344
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82
      pfam08221
      Location:7 → 65
      HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96618836..96634803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502188.5 → XP_006502251.1  DNA-directed RNA polymerase III subunit RPC3 isoform X2

      Conserved Domains (1) summary
      pfam05645
      Location:62 → 260
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82

    2. XM_030252855.2 → XP_030108715.1  DNA-directed RNA polymerase III subunit RPC3 isoform X2

      Conserved Domains (1) summary
      pfam05645
      Location:62 → 260
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82

    3. XM_006502187.5 → XP_006502250.1  DNA-directed RNA polymerase III subunit RPC3 isoform X1

      See identical proteins and their annotated locations for XP_006502250.1

      UniProtKB/Swiss-Prot
      Q8R0I2, Q9D483
      UniProtKB/TrEMBL
      B2RX77
      Related
      ENSMUSP00000122435.2, ENSMUST00000154679.8
      Conserved Domains (2) summary
      pfam05645
      Location:146 → 344
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82
      pfam08221
      Location:7 → 65
      HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

    RNA

    1. XR_867239.4 RNA Sequence

    2. XR_375595.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D483.1 GenPept UniProtKB/Swiss-Prot:Q9D483

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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