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    Aldoart2 aldolase 1 A, retrogene 2 [ Mus musculus (house mouse) ]

    Gene ID: 79459, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Aldoart2provided by MGI
    Official Full Name
    aldolase 1 A, retrogene 2provided by MGI
    Primary source
    MGI:MGI:1931052
    See related
    Ensembl:ENSMUSG00000063129 AllianceGenome:MGI:1931052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aldo1-ps1; Aldoa-ps1; 4933425L11Rik
    Summary
    Predicted to enable several functions, including fructose binding activity; fructose-bisphosphate aldolase activity; and identical protein binding activity. Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; fructose 1,6-bisphosphate metabolic process; and purine ribonucleotide metabolic process. Predicted to be located in actin cytoskeleton; extracellular exosome; and sperm head. Predicted to be active in cytosol. Is expressed in alimentary system; eye; nervous system; and trunk. Orthologous to human ALDOA (aldolase, fructose-bisphosphate A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Aldoart2 in Genome Data Viewer
    Location:
    12 C1; 12 24.04 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55611990..55613681)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55565205..55566896)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E473 Neighboring gene STARR-positive B cell enhancer ABC_E7134 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56600132-56600241 Neighboring gene STARR-seq mESC enhancer starr_32192 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Neighboring gene predicted gene, 36634 Neighboring gene STARR-seq mESC enhancer starr_32194 Neighboring gene Ral GTPase activating protein, alpha subunit 1 Neighboring gene insulinoma-associated 2 Neighboring gene STARR-seq mESC enhancer starr_32196 Neighboring gene STARR-seq mESC enhancer starr_32197 Neighboring gene STARR-positive B cell enhancer ABC_E11776

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution of Aldolase A pseudogenes in mice: multiple origins, subsequent duplications, and heterogeneity of evolutionary rates. Cortinas MN, et al. Mol Biol Evol, 2001 Sep. PMID 11504845
    2. Three male germline-specific aldolase A isozymes are generated by alternative splicing and retrotransposition. Vemuganti SA, et al. Dev Biol, 2007 Sep 1. PMID 17659271
    3. Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice. Tateno M, et al. Cancer Res, 2001 Feb 1. PMID 11221845
    4. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • 4933425L11Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fructose-bisphosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fructose-bisphosphate aldolase A-like
    Names
    aldolase A retroprotein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277340.1 → NP_001264269.1  fructose-bisphosphate aldolase A-like

      See identical proteins and their annotated locations for NP_001264269.1

      Status: VALIDATED

      Source sequence(s)
      AC158398, AK016920
      Consensus CDS
      CCDS70384.1
      UniProtKB/TrEMBL
      A6ZI47, Q6NY00
      Related
      ENSMUSP00000079022.2, ENSMUST00000080123.2
      Conserved Domains (1) summary
      pfam00274
      Location:15 → 364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      55611990..55613681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_005196.1: Suppressed sequence

      Description
      NG_005196.1: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
    Nucleotide Protein Strain
    Heading Accession and Version

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