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    Sh3yl1 SH3 and SYLF domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362724, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sh3yl1provided by RGD
    Official Full Name
    SH3 and SYLF domain containing 1provided by RGD
    Primary source
    RGD:1306440
    See related
    Ensembl:ENSRNOG00000005522 AllianceGenome:RGD:1306440
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatase binding activity and phosphatidylinositol binding activity. Predicted to act upstream of or within phosphatidylinositol biosynthetic process and regulation of ruffle assembly. Predicted to be active in ruffle membrane. Orthologous to human SH3YL1 (SH3 and SYLF domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 83.8), Spleen (RPKM 60.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh3yl1 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (53250036..53293406)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (47522098..47565858)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (49851778..49895502)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ALK and LTK ligand 2 Neighboring gene uncharacterized LOC134479359 Neighboring gene acid phosphatase 1 Neighboring gene HIRA interacting protein 3, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. Hasegawa J, et al. J Cell Biol, 2011 May 30. PMID 21624956, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ruffle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing YSC84-like protein 1
    Names
    SH3 domain containing, Ysc84-like 1
    Sh3 domain YSC-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108705.2 → NP_001102175.1  SH3 domain-containing YSC84-like protein 1

      See identical proteins and their annotated locations for NP_001102175.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158742
      UniProtKB/Swiss-Prot
      B0BNA1
      UniProtKB/TrEMBL
      A0A8I6GLW3, A6HB38
      Related
      ENSRNOP00000060428.2, ENSRNOT00000068208.3
      Conserved Domains (2) summary
      cd11525
      Location:11 → 209
      SYLF_SH3YL1_like; The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins
      cd11841
      Location:285 → 338
      SH3_SH3YL1_like; Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      53250036..53293406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239970.5 → XP_006240032.1  SH3 domain-containing YSC84-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6B697, A0A8I6GLW3
      Related
      ENSRNOP00000097804.1
      Conserved Domains (2) summary
      cd11525
      Location:11 → 209
      SYLF_SH3YL1_like; The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins
      cd11841
      Location:295 → 348
      SH3_SH3YL1_like; Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein

    2. XM_063262076.1 → XP_063118146.1  SH3 domain-containing YSC84-like protein 1 isoform X3

    3. XM_063262077.1 → XP_063118147.1  SH3 domain-containing YSC84-like protein 1 isoform X3

    4. XM_063262075.1 → XP_063118145.1  SH3 domain-containing YSC84-like protein 1 isoform X2

    RNA

    1. XR_005505541.2 RNA Sequence

    2. XR_010052117.1 RNA Sequence

    3. XR_010052118.1 RNA Sequence

    4. XR_005505542.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BNA1.1 GenPept UniProtKB/Swiss-Prot:B0BNA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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