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    Ppil2 peptidylprolyl isomerase like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360746, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ppil2provided by RGD
    Official Full Name
    peptidylprolyl isomerase like 2provided by RGD
    Primary source
    RGD:1309484
    See related
    Ensembl:ENSRNOG00000026900 AllianceGenome:RGD:1309484
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity and ubiquitin-ubiquitin ligase activity. Predicted to be involved in protein localization to plasma membrane; protein peptidyl-prolyl isomerization; and protein polyubiquitination. Predicted to be located in cytoplasm; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Orthologous to human PPIL2 (peptidylprolyl isomerase like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 173.2), Adrenal (RPKM 154.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppil2 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97401944..97424581)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83897719..83920970)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (88147342..88169968)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610318N02 gene like Neighboring gene microRNA 301b Neighboring gene microRNA 130b Neighboring gene yippee-like 1 Neighboring gene mitogen activated protein kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60. Pushkarsky T, et al. J Biol Chem, 2005 Jul 29. PMID 15946952
    2. Spliceosomal immunophilins. Mesa A, et al. FEBS Lett, 2008 Jul 9. PMID 18544344, Free PMC Article
    3. U box proteins as a new family of ubiquitin-protein ligases. Hatakeyama S, et al. J Biol Chem, 2001 Aug 31. PMID 11435423
    4. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. Davis TL, et al. PLoS Biol, 2010 Jul 27. PMID 20676357, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RING-type E3 ubiquitin-protein ligase PPIL2
    Names
    peptidyl-prolyl cis-trans isomerase-like 2
    peptidylprolyl isomerase (cyclophilin)-like 2
    NP_001017383.1
    XP_063126732.1
    XP_063126733.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017383.1 → NP_001017383.1  RING-type E3 ubiquitin-protein ligase PPIL2

      See identical proteins and their annotated locations for NP_001017383.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085890
      UniProtKB/TrEMBL
      A6JSN3, Q5RKH8
      Related
      ENSRNOP00000035467.5, ENSRNOT00000034506.5
      Conserved Domains (2) summary
      smart00504
      Location:42 → 96
      Ubox; Modified RING finger domain
      cd01923
      Location:281 → 440
      cyclophilin_RING; cyclophilin_RING: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      97401944..97424581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270662.1 → XP_063126732.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1

      UniProtKB/TrEMBL
      A6JSN3, F7FHL6

    2. XM_063270663.1 → XP_063126733.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X2

    RNA

    1. XR_010055963.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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