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    Btnl8 butyrophilin-like 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 406160, updated on 13-Apr-2024

    Summary

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    Symbol
    Btnl8provided by RGD
    Full Name
    butyrophilin-like 8provided by RGD
    Primary source
    RGD:1303010
    See related
    AllianceGenome:RGD:1303010
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human BTNL3 (butyrophilin like 3); BTNL8 (butyrophilin like 8); and BTN3A3 (butyrophilin subfamily 3 member A3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 4.7), Spleen (RPKM 3.3) and 6 other tissues See more
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    Genomic context

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    See Btnl8 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4268823..4282807)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4264840..4280876)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (2845720..2863449, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene complement C4B Neighboring gene cytochrome P450, family 21, subfamily a, polypeptide 1, pseudogene Neighboring gene butyrophilin-like 4 Neighboring gene butyrophilin-like 7 Neighboring gene butyrophilin-like 6, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Frontline: Characterization of BT3 molecules belonging to the B7 family expressed on immune cells. Compte E, et al. Eur J Immunol, 2004 Aug. PMID 15259006
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    butyrophilin-like 8
    Names
    butyrophilin subfamily 1 member A1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395869.1 → NP_001382798.1  butyrophilin-like 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8J8XT05
      Conserved Domains (2) summary
      smart00409
      Location:35 → 89
      IG; Immunoglobulin
      cd13733
      Location:288 → 445
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4268823..4282807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279340.1 → XP_063135410.1  butyrophilin-like 8 isoform X1

    2. XM_063279344.1 → XP_063135414.1  butyrophilin-like 8 isoform X4

    3. XM_063279339.1 → XP_063135409.1  butyrophilin-like 8 isoform X1

    4. XM_063279345.1 → XP_063135415.1  butyrophilin-like 8 isoform X5

    5. XM_063279341.1 → XP_063135411.1  butyrophilin-like 8 isoform X2

    6. XM_063279342.1 → XP_063135412.1  butyrophilin-like 8 isoform X3

    7. XM_063279346.1 → XP_063135416.1  butyrophilin-like 8 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001395863.1: Suppressed sequence

      Description
      NM_001395863.1: This RefSeq was removed because currently there is insufficient support for the transcript.

    2. NM_212489.1: Suppressed sequence

      Description
      NM_212489.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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