Septin6 septin 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Septin6provided by RGD
Official Full Name: septin 6provided by RGD
Primary source: RGD:1585082
See related: Ensembl:ENSRNOG00000043182 AllianceGenome:RGD:1585082
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sept6
Summary: Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cellular protein localization; cilium assembly; and cytoskeleton-dependent cytokinesis. Predicted to be located in several cellular components, including cleavage furrow; septin collar; and sperm annulus. Predicted to be part of septin complex. Predicted to be active in cell division site; cytoskeleton; and presynapse. Orthologous to human SEPTIN6 (septin 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 241.9), Spleen (RPKM 119.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq34

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (121018951..121157677, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (116153255..116230334, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (123524954..123601214, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

regulates various biological behaviors in hepatic stellate cells through TGF-beta1/Smad, mitogen-activated protein kinases and phosphatidylinositol-3-kinase/protein kinase B signaling pathways, thus promoting liver fibrosis
Title: Effect of SEPT6 on the biological behavior of hepatic stellate cells and liver fibrosis in rats and its mechanism.
Septin 6 regulates the cytoarchitecture of neurons through localization at dendritic branch points and bases of protrusions.
Title: Septin 6 regulates the cytoarchitecture of neurons through localization at dendritic branch points and bases of protrusions.

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General gene information

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Markers

DXGot53 (e-PCR)
- UniSTS:113665

RH144503 (e-PCR)
- UniSTS:233748

UniSTS:488532 (e-PCR)
- UniSTS:488532

DBX (e-PCR)
- UniSTS:266902

AI072432 (e-PCR)
- UniSTS:244987

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon terminus	ISO Inferred from Sequence Orthology more info
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in septin collar	ISO Inferred from Sequence Orthology more info
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	ISO Inferred from Sequence Orthology more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info
located_in septin ring	ISO Inferred from Sequence Orthology more info
located_in sperm annulus	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: septin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001173429.1 → NP_001166900.1 septin-6

See identical proteins and their annotated locations for NP_001166900.1

Status: PROVISIONAL

Source sequence(s)

BC169051

UniProtKB/TrEMBL

A0A0U1RRN9, A0A9K3Y7T9, B5DFG5, F1LRN3

Related

ENSRNOP00000061494.2, ENSRNOT00000067942.4

Conserved Domains (2) summary

cd01850
Location:39 → 307

CDC_Septin; CDC/Septin GTPase family

COG5019
Location:21 → 373

CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]