Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tal1provided by RGD
Official Full Name: TAL bHLH transcription factor 1, erythroid differentiation factorprovided by RGD
Primary source: RGD:1306748
See related: Ensembl:ENSRNOG00000025051 AllianceGenome:RGD:1306748
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tal-1
Summary: Predicted to enable several functions, including E-box binding activity; histone deacetylase binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Predicted to contribute to DNA binding activity. Predicted to be involved in several processes, including basophil differentiation; positive regulation of cellular component organization; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 222.3), Lung (RPKM 66.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (133823093..133837737)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (128586776..128600976)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (133864401..133878604)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAL-1 may be involved in cell division, morphological changes, and the development of spermatogenic cells in the normal rat testis
Title: Rat stem-cell leukemia gene expression increased during testis maturation.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129488 (e-PCR)
- UniSTS:212792

BE117264 (e-PCR)
- UniSTS:248658

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within astrocyte fate commitment	ISO Inferred from Sequence Orthology more info
involved_in basophil differentiation	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within definitive hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within generation of neurons	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemangioblast cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within megakaryocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mast cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord association neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-cell acute lymphocytic leukemia protein 1

Names: T-cell acute lymphocytic leukemia 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107958.2 → NP_001101428.2 T-cell acute lymphocytic leukemia protein 1

See identical proteins and their annotated locations for NP_001101428.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

D3Z921

Related

ENSRNOP00000034958.5, ENSRNOT00000035409.6

Conserved Domains (1) summary

cd19706
Location:185 → 249

bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

133823093..133837737

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238618.5 → XP_006238680.1 T-cell acute lymphocytic leukemia protein 1 isoform X2

See identical proteins and their annotated locations for XP_006238680.1

UniProtKB/TrEMBL

D3Z921

Related

ENSRNOP00000071897.2

Conserved Domains (1) summary

cd19706
Location:185 → 249

bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
XM_006238615.5 → XP_006238677.1 T-cell acute lymphocytic leukemia protein 1 isoform X2

See identical proteins and their annotated locations for XP_006238677.1

UniProtKB/TrEMBL

D3Z921

Conserved Domains (1) summary

cd19706
Location:185 → 249

bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
XM_063287732.1 → XP_063143802.1 T-cell acute lymphocytic leukemia protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K1M1
XM_039109984.2 → XP_038965912.1 T-cell acute lymphocytic leukemia protein 1 isoform X2

UniProtKB/TrEMBL

D3Z921

Conserved Domains (1) summary

cd19706
Location:185 → 249

bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
XM_039109985.2 → XP_038965913.1 T-cell acute lymphocytic leukemia protein 1 isoform X2

UniProtKB/TrEMBL

D3Z921

Conserved Domains (1) summary

cd19706
Location:185 → 249

bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
XM_008763967.3 → XP_008762189.1 T-cell acute lymphocytic leukemia protein 1 isoform X2

See identical proteins and their annotated locations for XP_008762189.1

UniProtKB/TrEMBL

D3Z921

Conserved Domains (1) summary

cd19706
Location:185 → 249

bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
XM_006238617.3 → XP_006238679.1 T-cell acute lymphocytic leukemia protein 1 isoform X2

See identical proteins and their annotated locations for XP_006238679.1

UniProtKB/TrEMBL

D3Z921

Conserved Domains (1) summary

cd19706
Location:185 → 249

bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
XM_039109986.1 → XP_038965914.1 T-cell acute lymphocytic leukemia protein 1 isoform X2

UniProtKB/TrEMBL

D3Z921

Conserved Domains (1) summary

cd19706
Location:185 → 249

bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins