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    Mdm1 Mdm1 nuclear protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314859, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Mdm1provided by RGD
    Official Full Name
    Mdm1 nuclear proteinprovided by RGD
    Primary source
    RGD:1561092
    See related
    Ensembl:ENSRNOG00000007286 AllianceGenome:RGD:1561092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in negative regulation of centriole replication and retina development in camera-type eye. Predicted to act upstream of or within photoreceptor cell maintenance. Predicted to be located in several cellular components, including cytosol; microtubule organizing center; and non-motile cilium. Orthologous to human MDM1 (Mdm1 nuclear protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 106.2), Testes (RPKM 102.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mdm1 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (55615459..55651889)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (53729603..53766034)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (61165652..61200865)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351463 Neighboring gene uncharacterized LOC134479695 Neighboring gene uncharacterized LOC102551023 Neighboring gene interleukin 22 Neighboring gene small ubiquitin-related modifier 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease. Hoh RA, et al. PLoS One, 2012. PMID 23300604, Free PMC Article
    2. Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene. Chang B, et al. Hum Mol Genet, 2008 Dec 15. PMID 18805803, Free PMC Article
    3. MDM1 is a microtubule-binding protein that negatively regulates centriole duplication. Van de Mark D, et al. Mol Biol Cell, 2015 Nov 1. PMID 26337392, Free PMC Article
    4. Mouse model resources for vision research. Won J, et al. J Ophthalmol, 2011. PMID 21052544, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of centriole replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retina development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear protein MDM1
    Names
    Mdm1 nuclear protein homolog
    transformed mouse 3T3 cell double minute 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017459.2 → NP_001017459.2  nuclear protein MDM1

      See identical proteins and their annotated locations for NP_001017459.2

      Status: VALIDATED

      Source sequence(s)
      BC087101, CB544747, CV126474
      UniProtKB/Swiss-Prot
      Q5PQN4
      UniProtKB/TrEMBL
      A6IGU8
      Related
      ENSRNOP00000041359.3, ENSRNOT00000048765.6
      Conserved Domains (1) summary
      pfam15501
      Location:9 → 554
      MDM1; Nuclear protein MDM1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      55615459..55651889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765400.4 → XP_008763622.1  nuclear protein MDM1 isoform X2

      UniProtKB/TrEMBL
      A6IGU8
      Related
      ENSRNOP00000075623.2
      Conserved Domains (1) summary
      pfam15501
      Location:6 → 551
      MDM1; Nuclear protein MDM1

    2. XM_063263492.1 → XP_063119562.1  nuclear protein MDM1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2KB24, A6IGU8

    3. XM_063263496.1 → XP_063119566.1  nuclear protein MDM1 isoform X10

    4. XM_063263489.1 → XP_063119559.1  nuclear protein MDM1 isoform X2

      UniProtKB/TrEMBL
      A6IGU8

    5. XM_063263491.1 → XP_063119561.1  nuclear protein MDM1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2KB24, A6IGU8

    6. XM_063263494.1 → XP_063119564.1  nuclear protein MDM1 isoform X8

      UniProtKB/TrEMBL
      A6IGU8

    7. XM_006241387.5 → XP_006241449.1  nuclear protein MDM1 isoform X3

      UniProtKB/TrEMBL
      A6IGU8
      Related
      ENSRNOP00000081317.1
      Conserved Domains (1) summary
      pfam15501
      Location:5 → 550
      MDM1; Nuclear protein MDM1

    8. XM_063263493.1 → XP_063119563.1  nuclear protein MDM1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZUT4, A6IGU8

    9. XM_063263495.1 → XP_063119565.1  nuclear protein MDM1 isoform X9

      UniProtKB/TrEMBL
      A6IGU8

    10. XM_006241385.5 → XP_006241447.1  nuclear protein MDM1 isoform X1

      UniProtKB/TrEMBL
      A6IGU8
      Conserved Domains (1) summary
      pfam15501
      Location:9 → 554
      MDM1; Nuclear protein MDM1

    11. XM_063263490.1 → XP_063119560.1  nuclear protein MDM1 isoform X5

      UniProtKB/TrEMBL
      A6IGU8

    12. XM_006241388.5 → XP_006241450.1  nuclear protein MDM1 isoform X4

      See identical proteins and their annotated locations for XP_006241450.1

      UniProtKB/TrEMBL
      A6IGU6, A6IGU8
      Related
      ENSRNOP00000091573.1
      Conserved Domains (1) summary
      pfam15501
      Location:9 → 544
      MDM1; Nuclear protein MDM1

    13. XM_039079129.2 → XP_038935057.1  nuclear protein MDM1 isoform X11

      Conserved Domains (1) summary
      pfam15501
      Location:6 → 249
      MDM1; Nuclear protein MDM1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQN4.2 GenPept UniProtKB/Swiss-Prot:Q5PQN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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