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    Pgpep1l pyroglutamyl-peptidase I-like [ Mus musculus (house mouse) ]

    Gene ID: 78444, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pgpep1lprovided by MGI
    Official Full Name
    pyroglutamyl-peptidase I-likeprovided by MGI
    Primary source
    MGI:MGI:1925694
    See related
    Ensembl:ENSMUSG00000030553 AllianceGenome:MGI:1925694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330024D12Rik
    Summary
    Predicted to enable cysteine-type peptidase activity. Predicted to be involved in proteolysis. Orthologous to human PGPEP1L (pyroglutamyl-peptidase I like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Pgpep1l in Genome Data Viewer
    Location:
    7 C; 7 37.47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (67881154..67914232, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (68235521..68264484, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19103 Neighboring gene predicted gene, 39027 Neighboring gene STARR-seq mESC enhancer starr_19104 Neighboring gene insulin-like growth factor I receptor Neighboring gene STARR-positive B cell enhancer ABC_E9692 Neighboring gene predicted gene, 51487 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:75350823-75351006 Neighboring gene STARR-positive B cell enhancer ABC_E8177 Neighboring gene STARR-seq mESC enhancer starr_19114 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:75434034-75434217 Neighboring gene family with sequence similarity 169, member B Neighboring gene aging liver Treg-expressed non-protein coding RNA Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:75468056-75468239 Neighboring gene predicted gene 16158

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice. Ikegami K, et al. Sci Rep, 2019 Sep 20. PMID 31541165, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyroglutamyl-peptidase 1-like protein
    NP_084377.1
    XP_006541378.1
    XP_017167887.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030101.1 → NP_084377.1  pyroglutamyl-peptidase 1-like protein

      Status: VALIDATED

      Source sequence(s)
      AC101879, AK021221, BY728828
      Consensus CDS
      CCDS52271.1
      UniProtKB/Swiss-Prot
      Q9CWB5
      UniProtKB/TrEMBL
      E9QM76
      Related
      ENSMUSP00000032770.3, ENSMUST00000032770.4
      Conserved Domains (1) summary
      cl00237
      Location:3 → 97
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      67881154..67914232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541315.4 → XP_006541378.1  pyroglutamyl-peptidase 1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A140LIX6
      Related
      ENSMUSP00000146996.2, ENSMUST00000207874.2
      Conserved Domains (1) summary
      cd00501
      Location:6 → 188
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

    2. XM_017312398.3 → XP_017167887.1  pyroglutamyl-peptidase 1-like protein isoform X1

      Conserved Domains (1) summary
      cl00237
      Location:6 → 162
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWB5.1 GenPept UniProtKB/Swiss-Prot:Q9CWB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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