Ptprs protein tyrosine phosphatase, receptor type, S [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprsprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Sprovided by RGD
Primary source: RGD:3452
See related: Ensembl:ENSRNOG00000047247 AllianceGenome:RGD:3452
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ptprd; Rptpd; Larptp2; Ptpsigma; Ptpsigma.
Summary: Enables protein tyrosine phosphatase activity. Involved in regulation of postsynaptic density assembly; regulation of presynapse assembly; and synaptic membrane adhesion. Is integral component of postsynaptic density membrane and integral component of synaptic vesicle membrane. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Orthologous to human PTPRS (protein tyrosine phosphatase receptor type S). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 331.4), Adrenal (RPKM 281.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (1332558..1394161, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (1245408..1307015, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (10585360..10646205)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enoxaparin promotes functional recovery after spinal cord injury by antagonizing PTPRsigma.
Title: Enoxaparin promotes functional recovery after spinal cord injury by antagonizing PTPRσ.
The present study found that astrocytes aberrantly and progressively expressed PTPsigma and LAR at the site of motor neuron degeneration in Tg ALS model rats with mutant SOD1.
Title: Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis.
Our study shows that modulation of PTPsigma is a potential therapeutic strategy for root avulsion.
Title: Enhanced regeneration and functional recovery after spinal root avulsion by manipulation of the proteoglycan receptor PTPσ.
PTPsigma functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.
Title: PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.
results add a new layer of understanding to the critical role of PTPsigma in mediating the growth-inhibited state of neurons due to CSPGs within the injured adult spinal cord
Title: Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury.
The changes in the coexpression of perineuronal nets, parvalbumin and PTPsigma provide valuable insights into the connection between chondroitin sulfates and parvalbumin neurons.
Title: Expression of perineuronal nets, parvalbumin and protein tyrosine phosphatase σ in the rat visual cortex during development and after BFD.
PTPSigma is a neuronal membrane receptor and has a role in rat presynaptic function and cell-cell communication.
Title: Protein-tyrosine phosphatase-sigma is a novel member of the functional family of alpha-latrotoxin receptors.
Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.
Title: Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptprs (e-PCR), detects polymorphism
- UniSTS:536492

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chondroitin sulfate binding	IEA Inferred from Electronic Annotation more info
enables chondroitin sulfate binding	ISO Inferred from Sequence Orthology more info
enables chondroitin sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparan sulfate proteoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebellum development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in corpus callosum development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within corpus callosum development	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial intestinal barrier	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of endothelial intestinal barrier	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon extension	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of axon regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of collateral sprouting	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collateral sprouting	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of dendritic spine development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interferon-alpha production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of toll-like receptor 9 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of toll-like receptor 9 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in presynapse assembly	EXP Inferred from Experiment more info	PubMed
involved_in presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic density assembly	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in spinal cord development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spinal cord development	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	IEA Inferred from Electronic Annotation more info
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase S

Names: LAR-PTP2; R-PTP-S; R-PTP-sigma; leukocyte common antigen-related protein-tyrosine phosphatase 2; leukocyte common antigen-related proten-tyrosine phosphatase 2; protein tyrosine phosphatase, receptor type, D; receptor-type tyrosine-protein phosphatase sigma

NP_062013.2

EC 3.1.3.48

XP_038938986.1

EC 3.1.3.48

XP_038938987.1

EC 3.1.3.48

XP_038938994.1

EC 3.1.3.48

XP_038938995.1

EC 3.1.3.48

XP_038938996.1

EC 3.1.3.48

XP_063122767.1

EC 3.1.3.48

XP_063122768.1

EC 3.1.3.48

XP_063122769.1

EC 3.1.3.48

XP_063122771.1

EC 3.1.3.48

XP_063122772.1

EC 3.1.3.48

XP_063122773.1

EC 3.1.3.48

XP_063122774.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019140.3 → NP_062013.2 receptor-type tyrosine-protein phosphatase S precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

M0R711

Related

ENSRNOP00000065227.3, ENSRNOT00000073991.4

Conserved Domains (9) summary

smart00060
Location:770 → 846

FN3; Fibronectin type 3 domain

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14625
Location:1285 → 1566

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1568 → 1857

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam18861
Location:1154 → 1238

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:137 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

1332558..1394161 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266704.1 → XP_063122774.1 receptor-type tyrosine-protein phosphatase S isoform X6
XM_063266703.1 → XP_063122773.1 receptor-type tyrosine-protein phosphatase S isoform X5
XM_063266701.1 → XP_063122771.1 receptor-type tyrosine-protein phosphatase S isoform X4
XM_063266699.1 → XP_063122769.1 receptor-type tyrosine-protein phosphatase S isoform X2
XM_039083058.2 → XP_038938986.1 receptor-type tyrosine-protein phosphatase S isoform X1

UniProtKB/TrEMBL

A0A8I5ZXU5, M0R711

Related

ENSRNOP00000084417.1

Conserved Domains (9) summary

smart00060
Location:823 → 899

FN3; Fibronectin type 3 domain

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14625
Location:1338 → 1619

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1621 → 1910

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam18861
Location:1207 → 1291

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:137 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
XM_039083067.2 → XP_038938995.1 receptor-type tyrosine-protein phosphatase S isoform X8

UniProtKB/TrEMBL

Q4JFL8

Conserved Domains (8) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14625
Location:919 → 1200

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1202 → 1491

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam18861
Location:792 → 876

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:137 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
XM_039083066.2 → XP_038938994.1 receptor-type tyrosine-protein phosphatase S isoform X7

UniProtKB/TrEMBL

Q4JFL8

Related

ENSRNOP00000084660.1

Conserved Domains (8) summary

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14625
Location:923 → 1204

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1206 → 1495

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam18861
Location:792 → 876

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:137 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
XM_063266702.1 → XP_063122772.1 receptor-type tyrosine-protein phosphatase S isoform X4
XM_039083059.2 → XP_038938987.1 receptor-type tyrosine-protein phosphatase S isoform X3

UniProtKB/Swiss-Prot

Q07808, Q3KRE9, Q64605, Q64621, Q64675

UniProtKB/TrEMBL

M0R711

Related

ENSRNOP00000084874.1

Conserved Domains (9) summary

smart00060
Location:814 → 890

FN3; Fibronectin type 3 domain

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14625
Location:1329 → 1610

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1612 → 1901

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam18861
Location:1198 → 1282

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cd05738
Location:137 → 226

IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains

cd05739
Location:235 → 316

IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
XM_063266697.1 → XP_063122767.1 receptor-type tyrosine-protein phosphatase S isoform X1

UniProtKB/TrEMBL

A0A8I5ZXU5
XM_063266698.1 → XP_063122768.1 receptor-type tyrosine-protein phosphatase S isoform X1

UniProtKB/TrEMBL

A0A8I5ZXU5
XM_039083068.2 → XP_038938996.1 receptor-type tyrosine-protein phosphatase S isoform X9

Conserved Domains (5) summary

smart00060
Location:217 → 293

FN3; Fibronectin type 3 domain

cd00063
Location:319 → 407

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14625
Location:732 → 1013

R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1

cd14627
Location:1015 → 1304

R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2

pfam18861
Location:601 → 685

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J