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    Wipf3 WAS/WASL interacting protein family, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259242, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Wipf3provided by RGD
    Official Full Name
    WAS/WASL interacting protein family, member 3provided by RGD
    Primary source
    RGD:708559
    See related
    Ensembl:ENSRNOG00000009571 AllianceGenome:RGD:708559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cr16
    Summary
    Enables SH3 domain binding activity. Predicted to be involved in actin filament-based movement. Predicted to be located in cytoplasm. Predicted to be active in actin filament. Orthologous to human WIPF3 (WAS/WASL interacting protein family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 40.0), Muscle (RPKM 19.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wipf3 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (84880403..84960250)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83550075..83629929)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84596305..84676775)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 beta 2, pseudogene 1 Neighboring gene proline rich 15 Neighboring gene secernin 1 Neighboring gene uncharacterized LOC102553885 Neighboring gene FKBP prolyl isomerase 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CR16, a novel proline-rich protein expressed in rat brain neurons, binds to SH3 domains and is a MAP kinase substrate. Weiler MC, et al. J Mol Neurosci, 1996 Fall. PMID 8906616
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of WASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of WASH complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WAS/WASL-interacting protein family member 3
    Names
    SH3 domain binding protein CR16
    corticosteroids and regional expression protein 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398730.1 → NP_001385659.1  WAS/WASL-interacting protein family member 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q62775, Q9Z0G8
      Related
      ENSRNOP00000064597.3, ENSRNOT00000074054.3
      Conserved Domains (1) summary
      cd22077
      Location:42 → 71
      WH2_WAS_WASL-2_3; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein (WIP) family members 2 and 3

    2. NM_147211.3 → NP_671744.1  WAS/WASL-interacting protein family member 3 isoform 2

      See identical proteins and their annotated locations for NP_671744.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8L2UNK9
      Related
      ENSRNOP00000012755.5, ENSRNOT00000012755.7
      Conserved Domains (1) summary
      pfam02205
      Location:45 → 69
      WH2; WH2 motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      84880403..84960250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107139.2 → XP_038963067.1  WAS/WASL-interacting protein family member 3 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UNK9
      Conserved Domains (1) summary
      cd22077
      Location:42 → 71
      WH2_WAS_WASL-2_3; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein (WIP) family members 2 and 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0G8.1 GenPept UniProtKB/Swiss-Prot:Q9Z0G8

    Gene LinkOut

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