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    Fgfbp1 fibroblast growth factor binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64535, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Fgfbp1provided by RGD
    Official Full Name
    fibroblast growth factor binding protein 1provided by RGD
    Primary source
    RGD:621211
    See related
    Ensembl:ENSRNOG00000003095 AllianceGenome:RGD:621211
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fibroblast growth factor binding activity. Involved in cell-cell signaling. Predicted to be located in cell surface and extracellular region. Orthologous to human FGFBP1 (fibroblast growth factor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 127.8), Lung (RPKM 123.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fgfbp1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (71316171..71319965)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (67103686..67107492)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (71647429..71650359)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096623 Neighboring gene U7 small nuclear RNA Neighboring gene prominin 1 Neighboring gene APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 Neighboring gene CD38 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effects on neurite outgrowth and cell survival of a secreted fibroblast growth factor binding protein upregulated during spinal cord injury. Tassi E, et al. Am J Physiol Regul Integr Comp Physiol, 2007 Aug. PMID 17553847
    2. Tissue distribution and retinoid-mediated downregulation of an FGF-binding protein (FGF-BP) in the rat. Aigner A, et al. Growth Factors, 2000. PMID 10831072
    3. Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells. Zhu HY, et al. Sci Rep, 2016 Apr 28. PMID 27121396, Free PMC Article
    4. Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2. West DC, et al. J Biol Chem, 2005 Apr 8. PMID 15695515
    5. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Beer HD, et al. Oncogene, 2005 Aug 11. PMID 15806171

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of myoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of myoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor-binding protein 1
    Names
    FGF-BP
    FGF-BP1
    FGF-binding protein 1
    FGFBP-1
    growth factor-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022603.2 → NP_072125.2  fibroblast growth factor-binding protein 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q9QY10
      UniProtKB/TrEMBL
      A6IJN7, G3V6D7
      Conserved Domains (1) summary
      pfam06473
      Location:15 → 233
      FGF-BP1; FGF binding protein 1 (FGF-BP1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      71316171..71319965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251079.5 → XP_006251141.1  fibroblast growth factor-binding protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9QY10
      Conserved Domains (1) summary
      pfam06473
      Location:9 → 196
      FGF-BP1; FGF binding protein 1 (FGF-BP1)

    2. XM_006251078.5 → XP_006251140.1  fibroblast growth factor-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006251140.1

      UniProtKB/Swiss-Prot
      Q9QY10
      UniProtKB/TrEMBL
      A6IJN7, G3V6D7
      Related
      ENSRNOP00000004128.3
      Conserved Domains (1) summary
      pfam06473
      Location:15 → 233
      FGF-BP1; FGF binding protein 1 (FGF-BP1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QY10.1 GenPept UniProtKB/Swiss-Prot:Q9QY10

    Gene LinkOut

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