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    Ecel1 endothelin converting enzyme-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60417, updated on 2-May-2024

    Summary

    Official Symbol
    Ecel1provided by RGD
    Official Full Name
    endothelin converting enzyme-like 1provided by RGD
    Primary source
    RGD:61806
    See related
    Ensembl:ENSRNOG00000019447 AllianceGenome:RGD:61806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dine
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in intracellular signal transduction and neuropeptide signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 7.0), Testes (RPKM 0.7) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ecel1 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95267417..95276508, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87819516..87829154, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94238568..94252484, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene alkaline phosphatase 3, intestine, not Mn requiring Neighboring gene uncharacterized LOC134480403 Neighboring gene serine protease 56 Neighboring gene cholinergic receptor nicotinic delta subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in respiratory system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in respiratory system process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in respiratory system process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    endothelin-converting enzyme-like 1
    Names
    damage-induced neuronal endopeptidase
    metallopeptidase
    xce protein
    NP_068544.2
    XP_017452104.1
    XP_063123735.1
    XP_063123736.1
    XP_063123737.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021776.3NP_068544.2  endothelin-converting enzyme-like 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q9JHL3, Q9Z192
      UniProtKB/TrEMBL
      A6JWK8, D4AD32
      Related
      ENSRNOP00000026388.4, ENSRNOT00000026387.7
      Conserved Domains (1) summary
      cd08662
      Location:121773
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      95267417..95276508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267666.1XP_063123736.1  endothelin-converting enzyme-like 1 isoform X1

    2. XM_063267665.1XP_063123735.1  endothelin-converting enzyme-like 1 isoform X1

    3. XM_017596615.3XP_017452104.1  endothelin-converting enzyme-like 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9JHL3, Q9Z192
      UniProtKB/TrEMBL
      A6JWK8, D4AD32
      Conserved Domains (1) summary
      cd08662
      Location:121773
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
    4. XM_063267667.1XP_063123737.1  endothelin-converting enzyme-like 1 isoform X1