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    Kcnk10 potassium two pore domain channel subfamily K member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65272, updated on 2-May-2024

    Summary

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    Official Symbol
    Kcnk10provided by RGD
    Official Full Name
    potassium two pore domain channel subfamily K member 10provided by RGD
    Primary source
    RGD:619732
    See related
    Ensembl:ENSRNOG00000003813 AllianceGenome:RGD:619732
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TREK2
    Summary
    Enables potassium channel activity. Involved in memory. Located in plasma membrane. Biomarker of brain ischemia. Orthologous to human KCNK10 (potassium two pore domain channel subfamily K member 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 36.4), Testes (RPKM 23.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnk10 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123419778..123555820, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (117690052..117826120, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122417079..122549532, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093266 Neighboring gene galactosylceramidase Neighboring gene G-protein coupled receptor 65 Neighboring gene uncharacterized LOC120103597 Neighboring gene U7 small nuclear RNA Neighboring gene spermatogenesis associated 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glial-derived neurotrophic factor regulates the expression of TREK2 in rat primary sensory neurons leading to attenuation of axotomy-induced neuropathic pain. Messina DN, et al. Exp Neurol, 2022 Nov. PMID 35907583
    2. Effects of GABA(B) receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation. Chang YT, et al. Mol Pain, 2021 Jan-Dec. PMID 34461754, Free PMC Article
    3. Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia. Rivera-Pagán AF, et al. PLoS One, 2015. PMID 25886567, Free PMC Article
    4. KCNK10, a tandem pore domain potassium channel, is a regulator of mitotic clonal expansion during the early stage of adipocyte differentiation. Nishizuka M, et al. Int J Mol Sci, 2014 Dec 9. PMID 25501330, Free PMC Article
    5. TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain. Acosta C, et al. J Neurosci, 2014 Jan 22. PMID 24453337, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glial-derived neurotrophic factor regulates the expression of TREK2 in rat primary sensory neurons leading to attenuation of axotomy-induced neuropathic pain.
      Title: Glial-derived neurotrophic factor regulates the expression of TREK2 in rat primary sensory neurons leading to attenuation of axotomy-induced neuropathic pain.
    2. Effects of GABAB receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation.
      Title: Effects of GABA(B) receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation.
    3. strong immunoreactivity of TRAAK, TREK-1 and TREK-2 channels was present mainly in small-sized dorsal root ganglion (DRG) neurons of rats.
      Title: Characterization of temperature-sensitive leak K(+) currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats.
    4. Data do not suggest a relevant impact of miRNA expression patterns on the pharmacoresponsiveness of temporal lobe epilepsy; but confirmed the regulation of the previously described miRNA-187-3p and demonstrated that its regulation can exert an impact on the expression of the two-pore domain potassium channel protein KCNK10/TREK-2.
      Title: miRNA-187-3p-Mediated Regulation of the KCNK10/TREK-2 Potassium Channel in a Rat Epilepsy Model.
    5. Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis.TREK-2 channels are up-regulated in the astrocytic membrane during ischemia.
      Title: Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia.
    6. KCNK10 contributes to the regulation of MCE through the control of C/EBPbeta and C/EBPdelta expression and insulin signaling.
      Title: KCNK10, a tandem pore domain potassium channel, is a regulator of mitotic clonal expansion during the early stage of adipocyte differentiation.
    7. We conclude that TREK2 hyperpolarizes IB4 binding C-nociceptors and limits pathological spontaneous pain.
      Title: TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain.
    8. In the dorsal horn of the developing rat, KCNK10 mRNA was decreased in mature compared with developing rats.
      Title: Transcriptional expression of voltage-gated Na⁺ and voltage-independent K⁺ channels in the developing rat superficial dorsal horn.
    9. These results suggest that baicalein- and wogonin-induced TREK-2 activation help set the resting membrane potential of cells exposed to pathological conditions and thus may give beneficial effects in neuroprotection.
      Title: Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel.
    10. GABA(B) receptor-mediated inhibition in the EC was mediated via activating TREK-2, a type of two-pore domain K(+) channels, and required the functions of inhibitory G proteins and protein kinase A pathway.
      Title: GABA(B) receptor activation inhibits neuronal excitability and spatial learning in the entorhinal cortex by activating TREK-2 K+ channels.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in memory IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel subfamily K member 10
    Names
    TREK-2 K(+) channel subunit
    outward rectifying potassium channel protein TREK-2
    potassium channel TREK-2
    potassium channel, subfamily K, member 10
    potassium channel, two pore domain subfamily K, member 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023096.3 → NP_075584.1  potassium channel subfamily K member 10

      See identical proteins and their annotated locations for NP_075584.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q548D8, Q9JIS4
      UniProtKB/TrEMBL
      A6JEE3
      Related
      ENSRNOP00000005175.3, ENSRNOT00000005175.5
      Conserved Domains (1) summary
      pfam07885
      Location:148 → 206
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      123419778..123555820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594351.3 → XP_017449840.1  potassium channel subfamily K member 10 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AXI0, A6JEE2
      Related
      ENSRNOP00000093775.1
      Conserved Domains (1) summary
      pfam07885
      Location:145 → 203
      Ion_trans_2; Ion channel

    2. XM_008764847.4 → XP_008763069.1  potassium channel subfamily K member 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AHS2
      Related
      ENSRNOP00000092512.1
      Conserved Domains (1) summary
      pfam07885
      Location:131 → 189
      Ion_trans_2; Ion channel

    3. XM_039112918.2 → XP_038968846.1  potassium channel subfamily K member 10 isoform X4

      Conserved Domains (1) summary
      pfam07885
      Location:148 → 206
      Ion_trans_2; Ion channel

    4. XM_063262460.1 → XP_063118530.1  potassium channel subfamily K member 10 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIS4.1 GenPept UniProtKB/Swiss-Prot:Q9JIS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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