Slc16a7 solute carrier family 16 member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc16a7provided by RGD
Official Full Name: solute carrier family 16 member 7provided by RGD
Primary source: RGD:3691
See related: Ensembl:ENSRNOG00000007839 AllianceGenome:RGD:3691
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mct2
Summary: Predicted to enable lactate transmembrane transporter activity and pyruvate transmembrane transporter activity. Involved in plasma membrane lactate transport. Located in cytoplasm and plasma membrane. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane. Orthologous to human SLC16A7 (solute carrier family 16 member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 249.5), Liver (RPKM 113.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (62929067..63096995, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (61043667..61211547, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (68438341..68606312, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Monocarboxylate transporter-2-knockout, which blocked the lactate shuttle in neurons, showed a remarkable decrease in the length of axons and dendrites. We further demonstrated that Akt activity was decreased while glycogen synthase kinase 3beta (GSK3beta) activity was increased after astrocytic glycogen phosphorylase blockade. Additionally, GSK3betaSer9 mutation reversed neurite growth failure caused by DAB and isofag...
Title: Lactate transport facilitates neurite outgrowth.
data not only demonstrate that glucose-derived lactate is locally produced following neuronal activation but also suggest that its use by neurons via MCT2 is probably essential to maintain synaptic activity within the barrel cortex
Title: A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation.
MPC inhibition is the most sensitive anti-tumour target for LND, with additional inhibitory effects on MCT-mediated L-lactic acid efflux and glutamine/glutamate oxidation.
Title: The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.
resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures occurs via an MCT-dependent mechanism.
Title: Monocarboxylate transporter-dependent mechanism confers resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures.
MCT2 increased in the hippocampus immediately after exercise and in the cortex and hypothalamus 5-24 h postexercise.
Title: Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins.
neuroplastins act as key ancillary proteins for MCT2 cell surface localisation and activity in some neuronal populations, thus playing an important role in facilitating the uptake of lactate for use as a respiratory fuel.
Title: The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface.
MCT2 distribution coupled with lactate uptake by hypothalamic neurons suggests that hypothalamic neurons control food intake using lactate to reflect changes in glucose levels.
Title: MCT2 expression and lactate influx in anorexigenic and orexigenic neurons of the arcuate nucleus.
MCT2 expression increases mainly in adult, not immature, rats with status epilepticus.
Title: Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat.
MCT2 response is suppressed in A2 noradrenergic neurons of recurring experimental hypoglycemia.
Title: Quantitative RT-PCR and immunoblot analyses reveal acclimated A2 noradrenergic neuron substrate fuel transporter, glucokinase, phospho-AMPK, and dopamine-β-hydroxylase responses to hypoglycemia.
Transfer of nicotinate from blood to retina across the inner blood-retinal barrier occurs primarily via H(+)-coupled monocarboxylate transporters.
Title: Retinal transfer of nicotinate by H+ -monocarboxylate transporter at the inner blood-retinal barrier.

Submit: New GeneRIF Correction See all GeneRIFs (25)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables lactate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lactate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables lactate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables monocarboxylic acid transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables pyruvate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyruvate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lactate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in lactate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane lactate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane lactate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in pyruvate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyruvate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: monocarboxylate transporter 2

Names: MCT 2; solute carrier family 16 (monocarboxylate transporter), member 7; solute carrier family 16 (monocarboxylic acid transporters), member 7; solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017302.2 → NP_058998.2 monocarboxylate transporter 2

See identical proteins and their annotated locations for NP_058998.2

Status: PROVISIONAL

Source sequence(s)

BC081701

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9

Conserved Domains (1) summary

TIGR00892
Location:21 → 436

2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

62929067..63096995 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241434.5 → XP_006241496.1 monocarboxylate transporter 2 isoform X1

See identical proteins and their annotated locations for XP_006241496.1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9

Conserved Domains (1) summary

TIGR00892
Location:21 → 436

2A0113; monocarboxylate transporter 1
XM_039078615.2 → XP_038934543.1 monocarboxylate transporter 2 isoform X1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9

Conserved Domains (1) summary

TIGR00892
Location:21 → 436

2A0113; monocarboxylate transporter 1
XM_039078614.2 → XP_038934542.1 monocarboxylate transporter 2 isoform X1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9

Conserved Domains (1) summary

TIGR00892
Location:21 → 436

2A0113; monocarboxylate transporter 1
XM_006241436.5 → XP_006241498.1 monocarboxylate transporter 2 isoform X1

See identical proteins and their annotated locations for XP_006241498.1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9

Conserved Domains (1) summary

TIGR00892
Location:21 → 436

2A0113; monocarboxylate transporter 1
XM_039078613.2 → XP_038934541.1 monocarboxylate transporter 2 isoform X1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9

Conserved Domains (1) summary

TIGR00892
Location:21 → 436

2A0113; monocarboxylate transporter 1
XM_063263138.1 → XP_063119208.1 monocarboxylate transporter 2 isoform X1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9
XM_039078612.2 → XP_038934540.1 monocarboxylate transporter 2 isoform X1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9

Conserved Domains (1) summary

TIGR00892
Location:21 → 436

2A0113; monocarboxylate transporter 1
XM_063263141.1 → XP_063119211.1 monocarboxylate transporter 2 isoform X3
XM_039078611.2 → XP_038934539.1 monocarboxylate transporter 2 isoform X1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9

Conserved Domains (1) summary

TIGR00892
Location:21 → 436

2A0113; monocarboxylate transporter 1
XM_063263139.1 → XP_063119209.1 monocarboxylate transporter 2 isoform X1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9
XM_006241435.5 → XP_006241497.1 monocarboxylate transporter 2 isoform X1

See identical proteins and their annotated locations for XP_006241497.1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9

Related

ENSRNOP00000054845.1

Conserved Domains (1) summary

TIGR00892
Location:21 → 436

2A0113; monocarboxylate transporter 1
XM_006241433.5 → XP_006241495.1 monocarboxylate transporter 2 isoform X1

See identical proteins and their annotated locations for XP_006241495.1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9

Conserved Domains (1) summary

TIGR00892
Location:21 → 436

2A0113; monocarboxylate transporter 1
XM_039078617.2 → XP_038934545.1 monocarboxylate transporter 2 isoform X3

Conserved Domains (1) summary

TIGR00892
Location:21 → 233

2A0113; monocarboxylate transporter 1
XM_039078616.2 → XP_038934544.1 monocarboxylate transporter 2 isoform X2

Conserved Domains (1) summary

TIGR00892
Location:1 → 297

2A0113; monocarboxylate transporter 1
XM_006241432.5 → XP_006241494.1 monocarboxylate transporter 2 isoform X1

See identical proteins and their annotated locations for XP_006241494.1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9

Conserved Domains (1) summary

TIGR00892
Location:21 → 436

2A0113; monocarboxylate transporter 1
XM_063263140.1 → XP_063119210.1 monocarboxylate transporter 2 isoform X1

UniProtKB/Swiss-Prot

Q63344, Q63649, Q66HS9