Mettl21c methyltransferase 21C, AARS1 lysine [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mettl21cprovided by RGD
Official Full Name: methyltransferase 21C, AARS1 lysineprovided by RGD
Primary source: RGD:1561425
See related: Ensembl:ENSRNOG00000011591 AllianceGenome:RGD:1561425
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561425
Summary: Predicted to enable heat shock protein binding activity and protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine trimethylation. Predicted to act upstream of or within cellular response to hormone stimulus; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and skeletal muscle tissue development. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human METTL21C (methyltransferase 21C, AARS1 lysine). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 138.0) and Heart (RPKM 4.3) See more
Orthologs: human all
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Genomic context

Location:: 9q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (53625473..53637220, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (46130451..46145128, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (50750971..50762082, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to dexamethasone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hormone-mediated apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine methylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein-lysine methyltransferase METTL21C

Names: methyltransferase like 21C; methyltransferase-like protein 21C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106908.1 → NP_001100378.1 protein-lysine methyltransferase METTL21C

See identical proteins and their annotated locations for NP_001100378.1

Status: PROVISIONAL

Source sequence(s)

CH473965

UniProtKB/TrEMBL

A6INS0, D3ZJG1

Related

ENSRNOP00000015490.5, ENSRNOT00000015492.6

Conserved Domains (1) summary

cl17173
Location:57 → 224

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

53625473..53637220 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596347.3 → XP_017451836.1 protein-lysine methyltransferase METTL21C isoform X1

UniProtKB/TrEMBL

A6INS0, D3ZJG1

Conserved Domains (1) summary

cl17173
Location:57 → 224

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039083266.2 → XP_038939194.1 protein-lysine methyltransferase METTL21C isoform X2