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    Cops7b COP9 signalosome subunit 7B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363273, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Cops7bprovided by RGD
    Official Full Name
    COP9 signalosome subunit 7Bprovided by RGD
    Primary source
    RGD:1306918
    See related
    Ensembl:ENSRNOG00000018723 AllianceGenome:RGD:1306918
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein deneddylation. Predicted to be located in nucleoplasm. Predicted to be part of COP9 signalosome. Orthologous to human COPS7B (COP9 signalosome subunit 7B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 43.2), Spleen (RPKM 34.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cops7b in Genome Data Viewer
    Location:
    9q35
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (94686314..94711903)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87238132..87263967)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (93607199..93633064)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene phosphodiesterase 6D Neighboring gene transfer RNA valine (anticodon AAC) 37 Neighboring gene uncharacterized LOC134480604 Neighboring gene uncharacterized LOC134480605 Neighboring gene natriuretic peptide C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Sharon M, et al. Structure, 2009 Jan 14. PMID 19141280
    2. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. Fang L, et al. J Proteome Res, 2008 Nov. PMID 18850735, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in COP9 signalosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 7b
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 7b
    COP9 constitutive photomorphogenic homolog subunit 7B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108807.2 → NP_001102277.1  COP9 signalosome complex subunit 7b

      See identical proteins and their annotated locations for NP_001102277.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JWJ3, D3ZU52
      Related
      ENSRNOP00000025411.4, ENSRNOT00000025411.7
      Conserved Domains (1) summary
      smart00753
      Location:146 → 235
      PAM; PCI/PINT associated module

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      94686314..94711903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083916.2 → XP_038939844.1  COP9 signalosome complex subunit 7b isoform X2

      UniProtKB/TrEMBL
      A6JWJ5
      Conserved Domains (2) summary
      smart00088
      Location:88 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    2. XM_006245414.5 → XP_006245476.1  COP9 signalosome complex subunit 7b isoform X1

      See identical proteins and their annotated locations for XP_006245476.1

      UniProtKB/TrEMBL
      A6JWJ3, D3ZU52
      Conserved Domains (1) summary
      smart00753
      Location:146 → 235
      PAM; PCI/PINT associated module
    Nucleotide Protein Strain
    Heading Accession and Version

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