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    Ercc5 ERCC excision repair 5, endonuclease [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301382, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ercc5provided by RGD
    Official Full Name
    ERCC excision repair 5, endonucleaseprovided by RGD
    Primary source
    RGD:1586176
    See related
    Ensembl:ENSRNOG00000022812 AllianceGenome:RGD:1586176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Xpg
    Summary
    Predicted to enable several functions, including DNA binding activity; RNA polymerase II complex binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including DNA repair; negative regulation of apoptotic process; and response to UV-C. Predicted to act upstream of or within UV protection; determination of adult lifespan; and nucleotide-excision repair. Predicted to be part of nucleotide-excision repair complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in cerebrooculofacioskeletal syndrome 3; melanoma; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 124.3), Heart (RPKM 115.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ercc5 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (53801471..53846611)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (46309477..46354478)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (50928847..50970962)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene testis expressed 30 Neighboring gene protein O-glucosyltransferase 2 Neighboring gene basic, immunoglobulin-like variable motif containing Neighboring gene methyltransferase like 21C-like 1 Neighboring gene cell division cycle associated 3 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Association between single nucleotide polymorphisms (SNPs) and toxicity of advanced non-small-cell lung cancer patients treated with chemotherapy. Zhang L, et al. PLoS One, 2012. PMID 23118991, Free PMC Article
    2. UV-induced apoptosis in XPG-deficient fibroblasts involves activation of CD95 and caspases but not p53. Clément V, et al. DNA Repair (Amst), 2007 May 1. PMID 17208056
    3. Suppression of UV-induced apoptosis by the human DNA repair protein XPG. Clément V, et al. Cell Death Differ, 2006 Mar. PMID 16167068
    4. Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG. Hohl M, et al. J Biol Chem, 2003 May 23. PMID 12644470
    5. Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. Cheng L, et al. Carcinogenesis, 2000 Aug. PMID 10910954

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bubble DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within UV protection ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in base-excision repair, AP site formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV-C ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleotide-excision repair complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA excision repair protein ERCC-5
    Names
    DNA repair protein complementing XP-G cells
    excision repair cross-complementation group 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426998.1 → NP_001413927.1  DNA excision repair protein ERCC-5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A096MKI6, D3ZTV2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      53801471..53846611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266934.1 → XP_063123004.1  DNA excision repair protein ERCC-5 isoform X2

      UniProtKB/TrEMBL
      A0A096MKI6

    2. XM_017596798.3 → XP_017452287.2  DNA excision repair protein ERCC-5 isoform X4

      UniProtKB/TrEMBL
      A6INS6
      Conserved Domains (1) summary
      TIGR00600
      Location:1 → 890
      rad2; DNA excision repair protein (rad2)

    3. XM_017596799.3 → XP_017452288.2  DNA excision repair protein ERCC-5 isoform X4

      UniProtKB/TrEMBL
      A6INS6
      Conserved Domains (1) summary
      TIGR00600
      Location:1 → 890
      rad2; DNA excision repair protein (rad2)

    4. XM_017596800.3 → XP_017452289.2  DNA excision repair protein ERCC-5 isoform X5

      UniProtKB/TrEMBL
      A6INS6
      Conserved Domains (1) summary
      TIGR00600
      Location:1 → 890
      rad2; DNA excision repair protein (rad2)

    5. XM_039084556.2 → XP_038940484.1  DNA excision repair protein ERCC-5 isoform X3

      UniProtKB/TrEMBL
      A6INS6
      Conserved Domains (1) summary
      TIGR00600
      Location:1 → 890
      rad2; DNA excision repair protein (rad2)

    6. XM_063266935.1 → XP_063123005.1  DNA excision repair protein ERCC-5 isoform X6

    7. XM_039084555.2 → XP_038940483.1  DNA excision repair protein ERCC-5 isoform X1

      UniProtKB/TrEMBL
      A0A096MKI6
      Related
      ENSRNOP00000068529.2
      Conserved Domains (1) summary
      TIGR00600
      Location:11 → 1007
      rad2; DNA excision repair protein (rad2)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106910.1: Suppressed sequence

      Description
      NM_001106910.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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