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    Rad17 RAD17 checkpoint clamp loader component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310034, updated on 2-May-2024

    Summary

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    Official Symbol
    Rad17provided by RGD
    Official Full Name
    RAD17 checkpoint clamp loader componentprovided by RGD
    Primary source
    RGD:1309515
    See related
    Ensembl:ENSRNOG00000018353 AllianceGenome:RGD:1309515
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including DNA repair; mitotic DNA integrity checkpoint signaling; and negative regulation of DNA replication. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Rad17 RFC-like complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human RAD17 (RAD17 checkpoint clamp loader component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 104.8), Testes (RPKM 94.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rad17 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33498335..33528614, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31764260..31794542, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30634353..30664618, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene bolA-like 1-like Neighboring gene uncharacterized LOC102557393 Neighboring gene MARVEL domain containing 2 Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6 Neighboring gene coiled-coil domain containing 125 Neighboring gene cyclin-dependent kinase 7 Neighboring gene KtI12 chromatin associated, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination. Budzowska M, et al. EMBO J, 2004 Sep 1. PMID 15297881, Free PMC Article
    2. HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation. Chang MS, et al. J Biol Chem, 1999 Dec 17. PMID 10593953
    3. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. Tsao CC, et al. EMBO J, 2004 Nov 24. PMID 15538388, Free PMC Article
    4. MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Wang Y, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14657349, Free PMC Article
    5. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Herbig U, et al. Mol Cell, 2004 May 21. PMID 15149599

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin-protein adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin-protein adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Rad17 RFC-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell cycle checkpoint protein RAD17
    Names
    RAD17 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024778.1 → NP_001019949.1  cell cycle checkpoint protein RAD17

      See identical proteins and their annotated locations for NP_001019949.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098057
      UniProtKB/TrEMBL
      Q4V7A2
      Related
      ENSRNOP00000024801.4, ENSRNOT00000024801.5
      Conserved Domains (2) summary
      TIGR00602
      Location:13 → 651
      rad24; checkpoint protein rad24
      pfam13238
      Location:133 → 253
      AAA_18; AAA domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      33498335..33528614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231848.4 → XP_006231910.1  cell cycle checkpoint protein RAD17 isoform X1

      UniProtKB/TrEMBL
      E9PTL1
      Conserved Domains (2) summary
      TIGR00602
      Location:13 → 651
      rad24; checkpoint protein rad24
      pfam13238
      Location:133 → 253
      AAA_18; AAA domain

    2. XM_039102173.2 → XP_038958101.1  cell cycle checkpoint protein RAD17 isoform X3

      Conserved Domains (1) summary
      TIGR00602
      Location:1 → 442
      rad24; checkpoint protein rad24

    3. XM_063281719.1 → XP_063137789.1  cell cycle checkpoint protein RAD17 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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