Slc40a1 solute carrier family 40 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Slc40a1provided by RGD
Full Name: solute carrier family 40 member 1provided by RGD
Primary source: RGD:620180
See related: Ensembl:ENSRNOG00000003872 AllianceGenome:RGD:620180
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fpn1; Slc11a3; Slc39a1
Summary: Predicted to enable ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Predicted to be involved in cellular iron ion homeostasis and iron ion export across plasma membrane. Predicted to act upstream of or within several processes, including multicellular organismal iron ion homeostasis; regulation of transcription by RNA polymerase II; and spleen trabecula formation. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and synaptic vesicle. Predicted to be active in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 1065.6), Liver (RPKM 270.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (55525457..55633463, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (48033526..48053876, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (52819451..52830461, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ferroportin-mediated ferroptosis involved in new-onset atrial fibrillation with LPS-induced endotoxemia.
Title: Ferroportin-mediated ferroptosis involved in new-onset atrial fibrillation with LPS-induced endotoxemia.
ata thereby indicate that heat stroke can decrease learning ability and memory in rats. The mechanism may be related to changes of iron levels, as well as Fpn1 and hepcidin expression, in the hippocampus.
Title: Dysfunction of Iron Metabolism and Iron-Regulatory Proteins in the Rat Hippocampus After Heat Stroke.
These data point towards a transcriptional induction of Fpn in response to changes in cellular iron levels.
Title: Hepcidin Mediates Transcriptional Changes in Ferroportin mRNA in Differentiated Neuronal-Like PC12 Cells Subjected to Iron Challenge.
Data suggest that expression of ferroportin in intestinal mucosa can be regulated by dietary factors; here, partially hydrolyzed guar gum up-regulates expression of ferroportin in cecum mucosa in growing rats being treated for iron deficiency anemia with this probiotic; intestinal absorption of dietary iron appears to be up-regulated, as well.
Title: Partially Hydrolyzed Guar Gum Increases Ferroportin Expression in the Colon of Anemic Growing Rats.
The significantly increased FPN1 level in small intestine facilitates digestive iron absorption, which maintains the serum iron concentration at a near-normal level to meet the increase of iron requirements
Title: Effects of Pregnancy and Lactation on Iron Metabolism in Rats.
DMT1 and FPN1 are positively influenced by ferrous iron status in brain after intracerebral hemorrhage. DMT1 and FPN1 attenuate iron overload after ICH via increasing transmembrane iron export.
Title: Changes of ferrous iron and its transporters after intracerebral hemorrhage in rats.
the effects of hepcidin expression and hepcidin peptide on brain iron contents, iron transport across the brain-blood barrier, iron uptake and release, and also the expression of TfR1, DMT1, and Fpn, were investigated.
Title: Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats.
Hepcidin or enterocyte iron levels may be involved in the regulation of the age-dependent expression in the duodenum.
Title: Age-dependent expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, and hephaestin in the duodenum of rats.
In ischemic rats, Fpn1 expression in the cerebral cortex and hippocampus was decreased.
Title: Quantitative analysis of iron concentration and expression of ferroportin 1 in the cortex and hippocampus of rats induced by cerebral ischemia.
Data suggest that expression of ferroportin (Slc40a1) in intestinal mucosa can be regulated by dietary factors; here, expression of ferroportin in mucosa of duodenum is down-regulated by prebiotic supplement, oligofructose, in iron-deficiency anemia.
Title: Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Rat60 (e-PCR), detects polymorphism
- UniSTS:228379

RH136898 (e-PCR)
- UniSTS:218987

Slc40a1 (e-PCR), detects polymorphism
- UniSTS:496015

RH129386 (e-PCR)
- UniSTS:212693

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ferrous iron transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables iron ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables iron ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables iron ion transmembrane transporter activity	NAS Non-traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in iron ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in iron ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iron ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in iron ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within iron ion transport	ISO Inferred from Sequence Orthology more info
involved_in iron ion transport	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within lymphocyte homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spleen development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spleen trabecula formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 40 member 1

Names: CAR1; cell adhesion regulator; ferroportin-1; solute carrier family 39 (iron-regulated transporter), member 1; solute carrier family 40 (iron-regulated transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133315.2 → NP_579849.2 solute carrier family 40 member 1

See identical proteins and their annotated locations for NP_579849.2

Status: VALIDATED

Source sequence(s)

AF394785, BI288312, CB808602, CK364414, CV104407, CV796629, DY313693

UniProtKB/Swiss-Prot

G3V6H7, Q923U9, Q9Z1C9

UniProtKB/TrEMBL

A0A9M1WP97, A6INT8

Related

ENSRNOP00000005228.3, ENSRNOT00000005228.4

Conserved Domains (1) summary

pfam06963
Location:22 → 530

FPN1; Ferroportin1 (FPN1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

55525457..55633463 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082988.2 → XP_038938916.1 solute carrier family 40 member 1 isoform X1

UniProtKB/Swiss-Prot

G3V6H7, Q923U9, Q9Z1C9

UniProtKB/TrEMBL

A0A9M1WP97, A6INT8

Conserved Domains (1) summary

pfam06963
Location:22 → 530

FPN1; Ferroportin1 (FPN1)
XM_063266613.1 → XP_063122683.1 solute carrier family 40 member 1 isoform X1

UniProtKB/Swiss-Prot

G3V6H7, Q923U9, Q9Z1C9

UniProtKB/TrEMBL

A6INT8