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    Tdrd9 tudor domain containing 9 [ Mus musculus (house mouse) ]

    Gene ID: 74691, updated on 12-May-2024

    Summary

    Official Symbol
    Tdrd9provided by MGI
    Official Full Name
    tudor domain containing 9provided by MGI
    Primary source
    MGI:MGI:1921941
    See related
    Ensembl:ENSMUSG00000054003 AllianceGenome:MGI:1921941
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930441E05Rik
    Summary
    Predicted to enable RNA binding activity. Involved in fertilization; gamete generation; and piRNA metabolic process. Acts upstream of or within negative regulation of transposition. Located in nucleus and piP-body. Is expressed in germ cell of testis. Human ortholog(s) of this gene implicated in spermatogenic failure 30. Orthologous to human TDRD9 (tudor domain containing 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 20.7) See more
    Orthologs
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    Genomic context

    See Tdrd9 in Genome Data Viewer
    Location:
    12 F1; 12 61.14 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111937922..112035288)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111971488..112068854)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36757 Neighboring gene STARR-positive B cell enhancer ABC_E8504 Neighboring gene ATP synthase membrane subunit j Neighboring gene retinal degeneration 3-like Neighboring gene predicted gene, 46381 Neighboring gene microRNA 3073a Neighboring gene microRNA 3073b Neighboring gene asparaginase Neighboring gene microRNA 203b Neighboring gene microRNA 203

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in piP-body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-dependent RNA helicase TDRD9
    Names
    putative ATP-dependent RNA helicase TDRD9
    tudor domain-containing protein 9
    NP_083332.1
    XP_006516379.1
    XP_006516380.1
    XP_006516382.1
    XP_006516383.1
    XP_006516384.1
    XP_006516385.1
    XP_017170707.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029056.1NP_083332.1  ATP-dependent RNA helicase TDRD9

      See identical proteins and their annotated locations for NP_083332.1

      Status: VALIDATED

      Source sequence(s)
      AB362563
      Consensus CDS
      CCDS49184.1
      UniProtKB/Swiss-Prot
      B1Q3J8, Q14AW6, Q14BI7
      Related
      ENSMUSP00000078022.6, ENSMUST00000079009.11
      Conserved Domains (2) summary
      COG1643
      Location:111717
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd20431
      Location:9061006
      Tudor_TDRD9; Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111937922..112035288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315218.2XP_017170707.1  ATP-dependent RNA helicase TDRD9 isoform X7

      Conserved Domains (1) summary
      COG1643
      Location:111717
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    2. XM_006516317.5XP_006516380.1  ATP-dependent RNA helicase TDRD9 isoform X2

      Conserved Domains (2) summary
      COG1643
      Location:111717
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam00567
      Location:9051014
      TUDOR; Tudor domain
    3. XM_006516316.3XP_006516379.1  ATP-dependent RNA helicase TDRD9 isoform X1

      Conserved Domains (2) summary
      COG1643
      Location:111680
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam00567
      Location:887996
      TUDOR; Tudor domain
    4. XM_006516320.4XP_006516383.1  ATP-dependent RNA helicase TDRD9 isoform X4

      Conserved Domains (2) summary
      COG1643
      Location:111695
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam00567
      Location:812921
      TUDOR; Tudor domain
    5. XM_006516319.3XP_006516382.1  ATP-dependent RNA helicase TDRD9 isoform X3

      Conserved Domains (2) summary
      COG1643
      Location:38644
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam00567
      Location:832941
      TUDOR; Tudor domain
    6. XM_006516321.3XP_006516384.1  ATP-dependent RNA helicase TDRD9 isoform X5

      See identical proteins and their annotated locations for XP_006516384.1

      UniProtKB/Swiss-Prot
      Q14BI7
      Conserved Domains (2) summary
      COG1643
      Location:13316
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam00567
      Location:504613
      TUDOR; Tudor domain
    7. XM_006516322.1XP_006516385.1  ATP-dependent RNA helicase TDRD9 isoform X6

      Conserved Domains (2) summary
      TIGR01967
      Location:1186
      DEAH_box_HrpA; RNA helicase HrpA
      pfam00567
      Location:379488
      TUDOR; Tudor domain

    RNA

    1. XR_381553.4 RNA Sequence

    2. XR_003950089.1 RNA Sequence