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    Nabp2 nucleic acid binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 69917, updated on 12-May-2024

    Summary

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    Official Symbol
    Nabp2provided by MGI
    Official Full Name
    nucleic acid binding protein 2provided by MGI
    Primary source
    MGI:MGI:1917167
    See related
    Ensembl:ENSMUSG00000025374 AllianceGenome:MGI:1917167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SSB1; Obfc2b; 2610036N15Rik
    Summary
    Predicted to enable DNA polymerase binding activity and G-rich strand telomeric DNA binding activity. Involved in DNA repair and positive regulation of telomere capping. Located in chromosome, telomeric region. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NABP2 (nucleic acid binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 13.1), whole brain E14.5 (RPKM 12.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nabp2 in Genome Data Viewer
    Location:
    10 D3; 10 76.55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128237263..128247426, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128401394..128411548, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 52 Neighboring gene microRNA 6915 Neighboring gene solute carrier family 39 (metal ion transporter), member 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127846873-127847141 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127848187-127848374 Neighboring gene STARR-positive B cell enhancer ABC_E6940 Neighboring gene ring finger protein 41 Neighboring gene predicted gene, 26347 Neighboring gene nuclear encoded tRNA serine 2 (anticodon CGA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Yu H, et al. Nat Neurosci, 2015 Jun. PMID 25915473, Free PMC Article
    2. NABP1, a novel RORgamma-regulated gene encoding a single-stranded nucleic-acid-binding protein. Kang HS, et al. Biochem J, 2006 Jul 1. PMID 16533169, Free PMC Article
    3. Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress. Shi W, et al. Blood, 2017 May 4. PMID 28270450, Free PMC Article
    4. SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors. Pfeifer M, et al. J Immunol, 2019 Jun 15. PMID 31085591, Free PMC Article
    5. Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres. Gu P, et al. Cell Res, 2013 May. PMID 23459151, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC30353

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G-rich strand telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization to telomere ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2/M transition checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ionizing radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SOSS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SOSS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SOSS complex subunit B1
    Names
    SOSS-B1
    oligonucleotide/oligosaccharide-binding fold containing 2B
    oligonucleotide/oligosaccharide-binding fold-containing protein 2B
    sensor of single-strand DNA complex subunit B1
    sensor of ssDNA subunit B1
    single-stranded DNA-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358972.1 → NP_001345901.1  SOSS complex subunit B1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC090489, BE988804, BX519720, CX238225
      Consensus CDS
      CCDS24276.1
      UniProtKB/Swiss-Prot
      Q8R2Y9
      UniProtKB/TrEMBL
      E9Q199
      Conserved Domains (2) summary
      PRK14971
      Location:106 → 179
      PRK14971; DNA polymerase III subunit gamma/tau
      cd04491
      Location:18 → 95
      SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

    2. NM_001358973.1 → NP_001345902.1  SOSS complex subunit B1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC090489, BE988804, BX519720, CX238225
      Conserved Domains (1) summary
      PRK14971
      Location:7 → 80
      PRK14971; DNA polymerase III subunit gamma/tau

    3. NM_027257.2 → NP_081533.1  SOSS complex subunit B1 isoform 1

      See identical proteins and their annotated locations for NP_081533.1

      Status: VALIDATED

      Source sequence(s)
      BE988804, BX519720, BY250791, CX238225
      Consensus CDS
      CCDS24276.1
      UniProtKB/Swiss-Prot
      Q8R2Y9
      UniProtKB/TrEMBL
      E9Q199
      Related
      ENSMUSP00000026439.8, ENSMUST00000026439.14
      Conserved Domains (2) summary
      PRK14971
      Location:106 → 179
      PRK14971; DNA polymerase III subunit gamma/tau
      cd04491
      Location:18 → 95
      SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128237263..128247426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514067.4 → XP_006514130.1  SOSS complex subunit B1 isoform X1

      See identical proteins and their annotated locations for XP_006514130.1

      UniProtKB/Swiss-Prot
      Q8R2Y9
      UniProtKB/TrEMBL
      E9Q199
      Conserved Domains (2) summary
      PRK14971
      Location:106 → 179
      PRK14971; DNA polymerase III subunit gamma/tau
      cd04491
      Location:18 → 95
      SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

    2. XM_036155988.1 → XP_036011881.1  SOSS complex subunit B1 isoform X1

      UniProtKB/Swiss-Prot
      Q8R2Y9
      UniProtKB/TrEMBL
      E9Q199
      Conserved Domains (2) summary
      PRK14971
      Location:106 → 179
      PRK14971; DNA polymerase III subunit gamma/tau
      cd04491
      Location:18 → 95
      SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

    3. XM_006514066.4 → XP_006514129.1  SOSS complex subunit B1 isoform X1

      See identical proteins and their annotated locations for XP_006514129.1

      UniProtKB/Swiss-Prot
      Q8R2Y9
      UniProtKB/TrEMBL
      E9Q199
      Conserved Domains (2) summary
      PRK14971
      Location:106 → 179
      PRK14971; DNA polymerase III subunit gamma/tau
      cd04491
      Location:18 → 95
      SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

    4. XM_030245253.2 → XP_030101113.1  SOSS complex subunit B1 isoform X1

      UniProtKB/Swiss-Prot
      Q8R2Y9
      UniProtKB/TrEMBL
      E9Q199
      Related
      ENSMUSP00000128634.2, ENSMUST00000164199.8
      Conserved Domains (2) summary
      PRK14971
      Location:106 → 179
      PRK14971; DNA polymerase III subunit gamma/tau
      cd04491
      Location:18 → 95
      SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

    5. XM_030245254.2 → XP_030101114.1  SOSS complex subunit B1 isoform X2

      Conserved Domains (1) summary
      PRK14971
      Location:7 → 80
      PRK14971; DNA polymerase III subunit gamma/tau
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2Y9.1 GenPept UniProtKB/Swiss-Prot:Q8R2Y9

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