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    Ptov1 prostate tumor over expressed gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 84113, updated on 12-May-2024

    Summary

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    Official Symbol
    Ptov1provided by MGI
    Official Full Name
    prostate tumor over expressed gene 1provided by MGI
    Primary source
    MGI:MGI:1933946
    See related
    Ensembl:ENSMUSG00000038502 AllianceGenome:MGI:1933946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcap3; 1110030G05Rik
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of transcription regulator complex. Is expressed in several structures, including central nervous system; gonad; lung; retina nuclear layer; and skeletal muscle. Orthologous to human PTOV1 (PTOV1 extended AT-hook containing adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 123.6), adrenal adult (RPKM 93.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptov1 in Genome Data Viewer
    Location:
    7 B3; 7 28.94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44512491..44523542, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44863067..44870519, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interleukin 4 induced 1B Neighboring gene interleukin 4 induced 1 Neighboring gene TBC1 domain family, member 17 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52112565-52112765 Neighboring gene AKT1 substrate 1 Neighboring gene microRNA 707 Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene mediator complex subunit 25 Neighboring gene STARR-positive B cell enhancer ABC_E8171 Neighboring gene STARR-positive B cell enhancer ABC_E547 Neighboring gene fuzzy planar cell polarity protein Neighboring gene adaptor-related protein complex 2, alpha 1 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks. Benedit P, et al. Oncogene, 2001 Mar 22. PMID 11313889
    2. PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development. Yao YW, et al. Histochem Cell Biol, 2011 Aug. PMID 21678139
    3. Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Kambouris M, et al. Brain Res Mol Brain Res, 1994 Sep. PMID 7808216
    4. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607
    5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development
      Title: PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prostate tumor-overexpressed gene 1 protein homolog
    Names
    granule cell antiserum positive 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133949.2 → NP_598710.1  prostate tumor-overexpressed gene 1 protein homolog

      See identical proteins and their annotated locations for NP_598710.1

      Status: VALIDATED

      Source sequence(s)
      AC158231
      Consensus CDS
      CCDS21219.1
      UniProtKB/Swiss-Prot
      Q91VU8, Q9CTC2
      Related
      ENSMUSP00000035281.10, ENSMUST00000046575.17
      Conserved Domains (1) summary
      pfam11232
      Location:93 → 238
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44512491..44523542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153604.1 → XP_036009497.1  prostate tumor-overexpressed gene 1 protein homolog isoform X2

      Conserved Domains (1) summary
      pfam11232
      Location:93 → 234
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

    2. XM_006541323.5 → XP_006541386.1  prostate tumor-overexpressed gene 1 protein homolog isoform X2

      Conserved Domains (1) summary
      pfam11232
      Location:93 → 234
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

    3. XM_036153603.1 → XP_036009496.1  prostate tumor-overexpressed gene 1 protein homolog isoform X1

      UniProtKB/Swiss-Prot
      Q91VU8, Q9CTC2
      Conserved Domains (1) summary
      pfam11232
      Location:93 → 238
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VU8.1 GenPept UniProtKB/Swiss-Prot:Q91VU8

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