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    Iba57 iron-sulfur cluster assembly factor IBA57 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363611, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Iba57provided by RGD
    Official Full Name
    iron-sulfur cluster assembly factor IBA57provided by RGD
    Primary source
    RGD:1306000
    See related
    Ensembl:ENSRNOG00000068756 AllianceGenome:RGD:1306000
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306000
    Summary
    Predicted to be involved in iron-sulfur cluster assembly. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 74 and multiple mitochondrial dysfunctions syndrome 3. Orthologous to human IBA57 (iron-sulfur cluster assembly factor IBA57). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 97.3), Heart (RPKM 81.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Iba57 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (44441579..44450368, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (43942017..43950807, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (45506124..45514909, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555997 Neighboring gene tripartite motif-containing 11 Neighboring gene uncharacterized LOC100911111 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene gap junction protein, gamma 2 Neighboring gene guanylate kinase 1 Neighboring gene mitochondrial ribosomal protein L55

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    putative transferase CAF17, mitochondrial
    Names
    IBA57 homolog, iron-sulfur cluster assembly
    IBA57 iron-sulfur cluster assembly
    IBA57, iron-sulfur cluster assembly homolog
    putative transferase CAF17 homolog, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108827.1 → NP_001102297.1  putative transferase CAF17, mitochondrial

      See identical proteins and their annotated locations for NP_001102297.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HEX8, D4ADG2
      Related
      ENSRNOP00000095371.1, ENSRNOT00000099520.1
      Conserved Domains (4) summary
      COG0354
      Location:53 → 352
      YgfZ; Folate-binding Fe-S cluster repair protein YgfZ, possible role in tRNA modification [Posttranslational modification, protein turnover, chaperones]
      TIGR03317
      Location:218 → 285
      ygfZ_signature; folate-binding protein YgfZ
      pfam08669
      Location:259 → 327
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      cl01893
      Location:59 → 117
      GCV_T; Aminomethyltransferase folate-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      44441579..44450368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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