Atp6v1c2 ATPase H+ transporting V1 subunit C2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp6v1c2provided by RGD
Official Full Name: ATPase H+ transporting V1 subunit C2provided by RGD
Primary source: RGD:1359430
See related: Ensembl:ENSRNOG00000050553 AllianceGenome:RGD:1359430
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in positive regulation of Wnt signaling pathway. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Orthologous to human ATP6V1C2 (ATPase H+ transporting V1 subunit C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 207.5), Kidney (RPKM 81.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (45809269..45872914, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (40080545..40144199, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (42585452..42632289, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes
Title: Differential expression of a V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes.

Submit: New GeneRIF Correction

General gene information

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Markers

Atp6v1c2 (e-PCR), detects polymorphism
- UniSTS:527053

RH127360 (e-PCR)
- UniSTS:210670

RH140843 (e-PCR)
- UniSTS:210670

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables proton-transporting ATPase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of proton-transporting V-type ATPase, V1 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: V-type proton ATPase subunit C 2

Names: ATPase, H+ transporting, V1 subunit C; ATPase, H+ transporting, lysosomal V1 subunit C2; V-ATPase subunit C 2; vacuolar H+ ATPase C2; vacuolar proton pump subunit C 2

NP_001014221.1

EC 7.1.2.2

XP_017449730.2

EC 7.1.2.2

XP_038968527.1

EC 7.1.2.2

XP_038968528.1

EC 7.1.2.2

XP_038968532.1

EC 7.1.2.2

XP_038968535.1

EC 7.1.2.2

XP_063118235.1

EC 7.1.2.2

XP_063118236.1

EC 7.1.2.2

XP_063118237.1

EC 7.1.2.2

XP_063118238.1

EC 7.1.2.2

XP_063118239.1

EC 7.1.2.2

XP_063118240.1

EC 7.1.2.2

XP_063118241.1

EC 7.1.2.2

XP_063118242.1

EC 7.1.2.2

XP_063118243.1

EC 7.1.2.2

XP_063118244.1

EC 7.1.2.2

XP_063118245.1

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014199.1 → NP_001014221.1 V-type proton ATPase subunit C 2

See identical proteins and their annotated locations for NP_001014221.1

Status: PROVISIONAL

Source sequence(s)

BC079083

UniProtKB/Swiss-Prot

Q53B80, Q6AYE4

UniProtKB/TrEMBL

A0A0G2JZN3

Related

ENSRNOP00000066981.3, ENSRNOT00000071977.3

Conserved Domains (2) summary

cd14785
Location:55 → 75

V-ATPase_C; 3-helical coiled coil [structural motif]

pfam03223
Location:5 → 415

V-ATPase_C; V-ATPase subunit C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

45809269..45872914 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262173.1 → XP_063118243.1 V-type proton ATPase subunit C 2 isoform X4

UniProtKB/TrEMBL

A0A0G2JZN3
XM_063262171.1 → XP_063118241.1 V-type proton ATPase subunit C 2 isoform X3

UniProtKB/TrEMBL

A0A0G2JZN3
XM_039112600.2 → XP_038968528.1 V-type proton ATPase subunit C 2 isoform X1

UniProtKB/TrEMBL

A0A0G2JZN3

Conserved Domains (2) summary

cd14785
Location:55 → 98

V-ATPase_C; 3-helical coiled coil [structural motif]

pfam03223
Location:5 → 438

V-ATPase_C; V-ATPase subunit C
XM_039112604.2 → XP_038968532.1 V-type proton ATPase subunit C 2 isoform X2

UniProtKB/Swiss-Prot

Q53B80, Q6AYE4

UniProtKB/TrEMBL

A0A0G2JZN3

Conserved Domains (2) summary

cd14785
Location:55 → 75

V-ATPase_C; 3-helical coiled coil [structural motif]

pfam03223
Location:5 → 415

V-ATPase_C; V-ATPase subunit C
XM_039112599.2 → XP_038968527.1 V-type proton ATPase subunit C 2 isoform X1

UniProtKB/TrEMBL

A0A0G2JZN3

Conserved Domains (2) summary

cd14785
Location:55 → 98

V-ATPase_C; 3-helical coiled coil [structural motif]

pfam03223
Location:5 → 438

V-ATPase_C; V-ATPase subunit C
XM_063262167.1 → XP_063118237.1 V-type proton ATPase subunit C 2 isoform X2

UniProtKB/Swiss-Prot

Q53B80, Q6AYE4

UniProtKB/TrEMBL

A0A0G2JZN3
XM_063262174.1 → XP_063118244.1 V-type proton ATPase subunit C 2 isoform X4

UniProtKB/TrEMBL

A0A0G2JZN3
XM_063262165.1 → XP_063118235.1 V-type proton ATPase subunit C 2 isoform X1

UniProtKB/TrEMBL

A0A0G2JZN3
XM_063262170.1 → XP_063118240.1 V-type proton ATPase subunit C 2 isoform X3

UniProtKB/TrEMBL

A0A0G2JZN3
XM_063262169.1 → XP_063118239.1 V-type proton ATPase subunit C 2 isoform X2

UniProtKB/Swiss-Prot

Q53B80, Q6AYE4

UniProtKB/TrEMBL

A0A0G2JZN3
XM_063262175.1 → XP_063118245.1 V-type proton ATPase subunit C 2 isoform X4

UniProtKB/TrEMBL

A0A0G2JZN3
XM_063262172.1 → XP_063118242.1 V-type proton ATPase subunit C 2 isoform X4

UniProtKB/TrEMBL

A0A0G2JZN3
XM_063262166.1 → XP_063118236.1 V-type proton ATPase subunit C 2 isoform X2

UniProtKB/Swiss-Prot

Q53B80, Q6AYE4

UniProtKB/TrEMBL

A0A0G2JZN3
XM_017594241.3 → XP_017449730.2 V-type proton ATPase subunit C 2 isoform X1

UniProtKB/TrEMBL

A0A0G2JZN3

Conserved Domains (2) summary

cd14785
Location:55 → 98

V-ATPase_C; 3-helical coiled coil [structural motif]

pfam03223
Location:5 → 438

V-ATPase_C; V-ATPase subunit C
XM_063262168.1 → XP_063118238.1 V-type proton ATPase subunit C 2 isoform X2

UniProtKB/Swiss-Prot

Q53B80, Q6AYE4

UniProtKB/TrEMBL

A0A0G2JZN3
XM_039112607.2 → XP_038968535.1 V-type proton ATPase subunit C 2 isoform X5

UniProtKB/TrEMBL

M0RBN8

Conserved Domains (2) summary

cd14785
Location:76 → 102

V-ATPase_C; 3-helical coiled coil [structural motif]

pfam03223
Location:22 → 371

V-ATPase_C; V-ATPase subunit C