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    Creld2 cysteine-rich with EGF-like domains 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362978, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Creld2provided by RGD
    Official Full Name
    cysteine-rich with EGF-like domains 2provided by RGD
    Primary source
    RGD:1310614
    See related
    Ensembl:ENSRNOG00000004659 AllianceGenome:RGD:1310614
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310614
    Summary
    Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Orthologous to human CRELD2 (cysteine rich with EGF like domains 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 251.3), Spleen (RPKM 193.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Creld2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (121788754..121796230)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (119909626..119916556)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (129812746..129819641)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547254 Neighboring gene zinc finger, BED-type containing 4 Neighboring gene ALG12, alpha-1,6-mannosyltransferase Neighboring gene transfer RNA leucine (anticodon AAG) 11 Neighboring gene Pim-3 proto-oncogene, serine/threonine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis and secretion of mouse cysteine-rich with EGF-like domains 2. Oh-hashi K, et al. FEBS Lett, 2011 Aug 4. PMID 21729698
    2. CRELD2 is a novel endoplasmic reticulum stress-inducible gene. Oh-hashi K, et al. Biochem Biophys Res Commun, 2009 Sep 25. PMID 19615339
    3. The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits. Ortiz JA, et al. J Neurochem, 2005 Dec. PMID 16238698
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC112714

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide isomerase Creld2
    Names
    cysteine-rich with EGF-like domain protein 2
    NP_001032285.1
    XP_006242278.1
    XP_063120016.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037208.1 → NP_001032285.1  protein disulfide isomerase Creld2 precursor

      See identical proteins and their annotated locations for NP_001032285.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098722
      UniProtKB/Swiss-Prot
      Q4G063
      UniProtKB/TrEMBL
      A0A8I6G5R7, A6K7H8
      Related
      ENSRNOP00000006357.5, ENSRNOT00000006357.6
      Conserved Domains (2) summary
      smart00261
      Location:191 → 227
      FU; Furin-like repeats
      cl00057
      Location:281 → 325
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      121788754..121796230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263946.1 → XP_063120016.1  protein disulfide isomerase Creld2 isoform X1

      UniProtKB/Swiss-Prot
      Q4G063
      UniProtKB/TrEMBL
      A6K7H8

    2. XM_006242216.5 → XP_006242278.1  protein disulfide isomerase Creld2 isoform X2

      Conserved Domains (2) summary
      smart00261
      Location:134 → 168
      FU; Furin-like repeats
      cl00057
      Location:222 → 266
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G063.1 GenPept UniProtKB/Swiss-Prot:Q4G063

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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