Nrf1 nuclear respiratory factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nrf1provided by RGD
Official Full Name: nuclear respiratory factor 1provided by RGD
Primary source: RGD:1304603
See related: Ensembl:ENSRNOG00000008752 AllianceGenome:RGD:1304603
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nfe2l1_retired
Summary: This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Confusion has occurred in bibliographic databases for genes in the "nuclear respiratory factor" and "nuclear factor (erythroid-derived 2)-like" families due to a shared symbol or alias of Nrf1. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Thymus (RPKM 147.5), Spleen (RPKM 95.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (59632366..59738166)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (58664932..58772328)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (57335732..57445317)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of 12-wk Training in Ovariectomised Rats on PGC-1alpha, NRF-1 and Energy Substrates.
Title: Effect of 12-wk Training in Ovariectomised Rats on PGC-1α, NRF-1 and Energy Substrates.
Effects of NRF-1 and PGC-1alpha cooperation on HIF-1alpha and rat cardiomyocyte apoptosis under hypoxia.
Title: Effects of NRF-1 and PGC-1α cooperation on HIF-1α and rat cardiomyocyte apoptosis under hypoxia.
Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function.
Title: Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function.
Testosterone attenuates pulmonary epithelial inflammation in male rats of COPD model through preventing NRF1-derived NF-kappaB signaling.
Title: Testosterone attenuates pulmonary epithelial inflammation in male rats of COPD model through preventing NRF1-derived NF-κB signaling.
Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway.
Title: Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway.
NRF1-enhanced miR-4458 alleviates cardiac hypertrophy through releasing TTP-inhibited TFAM.
Title: NRF1-enhanced miR-4458 alleviates cardiac hypertrophy through releasing TTP-inhibited TFAM.
Identification of microRNA3633p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53signaling pathway.
Title: Identification of microRNA‑363‑3p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53‑signaling pathway.
NRF1 regulates testosterone synthesis through transcription regulation of Star.
Title: Transcription regulation of NRF1 on StAR reduces testosterone synthesis in hypoxemic murine.
the present study demonstrated that NRF1 protected against CoCl2induced apoptosis, potentially by strengthening mitochondrial function to resist CoCl2induced damage to H9C2 cells. The results of the present study provide a possible way for the investigation of myocardial diseases.
Title: Effects of nuclear respiratory factor‑1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells.
Our findings suggest that NRF-1 regulates the expression of CXCR4 in normal retinal development and in pathologic processes of retinal hypoxia and neovascularization.
Title: Nuclear Respiratory Factor-1 (NRF-1) Regulates Transcription of the CXC Receptor 4 (CXCR4) in the Rat Retina.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE096654 (e-PCR)
- UniSTS:260647

RH127210 (e-PCR)
- UniSTS:167487

Nrf1 (e-PCR), detects polymorphism
- UniSTS:496724

RH130830 (e-PCR)
- UniSTS:214114

RH136651 (e-PCR)
- UniSTS:218742

BF387640 (e-PCR)
- UniSTS:244430

PMC97559P1 (e-PCR)
- UniSTS:273651

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to folic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear respiratory factor 1

Names: NRF-1; alpha palindromic-binding protein; alpha-pal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100708.1 → NP_001094178.1 nuclear respiratory factor 1

See identical proteins and their annotated locations for NP_001094178.1

Status: PROVISIONAL

Source sequence(s)

BC161956

UniProtKB/TrEMBL

A6IEF3, B1WC04, F7FCI9

Related

ENSRNOP00000011851.2, ENSRNOT00000011851.4

Conserved Domains (2) summary

cd04867
Location:450 → 525

TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins

pfam10491
Location:87 → 283

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

59632366..59738166

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107511.2 → XP_038963439.1 nuclear respiratory factor 1 isoform X3

UniProtKB/TrEMBL

A0A0G2KA43

Related

ENSRNOP00000075252.2

Conserved Domains (2) summary

pfam10492
Location:462 → 505

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:87 → 295

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
XM_006236200.5 → XP_006236262.1 nuclear respiratory factor 1 isoform X8

Conserved Domains (2) summary

pfam10492
Location:470 → 523

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:87 → 283

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
XM_006236198.5 → XP_006236260.1 nuclear respiratory factor 1 isoform X4

See identical proteins and their annotated locations for XP_006236260.1

UniProtKB/TrEMBL

A0A8I6ALN8, A6IEF2

Conserved Domains (2) summary

pfam10492
Location:450 → 493

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:87 → 283

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
XM_063285983.1 → XP_063142053.1 nuclear respiratory factor 1 isoform X3

UniProtKB/TrEMBL

A0A0G2KA43
XM_063285984.1 → XP_063142054.1 nuclear respiratory factor 1 isoform X4

UniProtKB/TrEMBL

A6IEF2
XM_017592611.3 → XP_017448100.1 nuclear respiratory factor 1 isoform X1

Conserved Domains (2) summary

cd04867
Location:462 → 537

TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins

pfam10491
Location:87 → 295

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
XM_017592612.3 → XP_017448101.1 nuclear respiratory factor 1 isoform X1

Conserved Domains (2) summary

cd04867
Location:462 → 537

TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins

pfam10491
Location:87 → 295

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
XM_063285982.1 → XP_063142052.1 nuclear respiratory factor 1 isoform X2

UniProtKB/TrEMBL

A6IEF3, B1WC04, F7FCI9
XM_039107513.2 → XP_038963441.1 nuclear respiratory factor 1 isoform X6

UniProtKB/TrEMBL

A0A8I6ALN8

Conserved Domains (1) summary

pfam10491
Location:87 → 295

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
XM_039107512.2 → XP_038963440.1 nuclear respiratory factor 1 isoform X5

UniProtKB/TrEMBL

A0A8I6ALN8

Conserved Domains (1) summary

pfam10491
Location:87 → 295

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
XM_039107514.2 → XP_038963442.1 nuclear respiratory factor 1 isoform X7

UniProtKB/TrEMBL

A0A8I5ZWF5, A0A8I6ALN8

Related

ENSRNOP00000083755.1

Conserved Domains (1) summary

pfam10491
Location:87 → 283

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
XM_063285985.1 → XP_063142055.1 nuclear respiratory factor 1 isoform X7

UniProtKB/TrEMBL

A0A8I5ZWF5