Spint2 serine peptidase inhibitor, Kunitz type, 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spint2provided by RGD
Official Full Name: serine peptidase inhibitor, Kunitz type, 2provided by RGD
Primary source: RGD:735123
See related: Ensembl:ENSRNOG00000020636 AllianceGenome:RGD:735123
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pb; HAI-2
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cellular response to BMP stimulus and negative regulation of neural precursor cell proliferation. Located in plasma membrane. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 1506.7), Lung (RPKM 690.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (93685637..93708091, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (84558159..84580616, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (87199373..87221826, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BI286409 (e-PCR)
- UniSTS:245321

Spint1 (e-PCR), detects polymorphism
- UniSTS:502733

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within basement membrane organization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within epithelial cell morphogenesis involved in placental branching	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment or maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kunitz-type protease inhibitor 2

Names: hepatocyte growth factor activator inhibitor type 2; placental bikunin; serine protease inhibitor, Kunitz type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082549.1 → NP_001076018.1 kunitz-type protease inhibitor 2 isoform a precursor

See identical proteins and their annotated locations for NP_001076018.1

Status: VALIDATED

Source sequence(s)

BC061768, DN934634

UniProtKB/TrEMBL

A6J9Q4, F6QKA3, G3V8S0

Related

ENSRNOP00000043981.3, ENSRNOT00000046611.5

Conserved Domains (1) summary

pfam00014
Location:38 → 88

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
NM_199087.1 → NP_954518.1 kunitz-type protease inhibitor 2 isoform b precursor

See identical proteins and their annotated locations for NP_954518.1

Status: VALIDATED

Source sequence(s)

BC061768

UniProtKB/TrEMBL

Q6P796

Conserved Domains (1) summary

pfam00014
Location:73 → 124

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain