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    Mospd2 motile sperm domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363463, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Mospd2provided by RGD
    Official Full Name
    motile sperm domain containing 2provided by RGD
    Primary source
    RGD:1563952
    See related
    Ensembl:ENSRNOG00000003350 AllianceGenome:RGD:1563952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563952
    Summary
    Predicted to be involved in positive regulation of monocyte chemotaxis and positive regulation of neutrophil chemotaxis. Predicted to be located in endoplasmic reticulum and endoplasmic reticulum-endosome membrane contact site. Predicted to be integral component of plasma membrane. Orthologous to human MOSPD2 (motile sperm domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 111.8), Spleen (RPKM 105.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mospd2 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (33052063..33105550)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (29420485..29472099)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (31140967..31182823)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RNA binding protein with serine rich domain 1 like 1 Neighboring gene FA complementation group B Neighboring gene thyroid hormone receptor associated protein 3, pseudogene 1 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of Motile Sperm Domain-Containing Protein 2 as Regulator of Human Monocyte Migration. Mendel I, et al. J Immunol, 2017 Mar 1. PMID 28137892, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FFAT motif binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum-endosome membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-endosome membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    motile sperm domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398727.1 → NP_001385656.1  motile sperm domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2K8D1
      Related
      ENSRNOP00000074561.1, ENSRNOT00000084395.2
      Conserved Domains (2) summary
      pfam00635
      Location:327 → 431
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:93 → 234
      CRAL_TRIO; CRAL/TRIO domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      33052063..33105550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099873.2 → XP_038955801.1  motile sperm domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      D4A4X7
      Conserved Domains (2) summary
      pfam00635
      Location:327 → 431
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:93 → 234
      CRAL_TRIO; CRAL/TRIO domain

    2. XM_006256866.5 → XP_006256928.1  motile sperm domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6K2K0
      Conserved Domains (2) summary
      pfam00635
      Location:327 → 431
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:93 → 234
      CRAL_TRIO; CRAL/TRIO domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134588.1: Suppressed sequence

      Description
      NM_001134588.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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