Stmn3 stathmin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stmn3provided by RGD
Official Full Name: stathmin 3provided by RGD
Primary source: RGD:3628
See related: Ensembl:ENSRNOG00000013657 AllianceGenome:RGD:3628
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sclip
Summary: Enables protein C-terminus binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; negative regulation of Rac protein signal transduction; and regulation of microtubule polymerization or depolymerization. Predicted to act upstream of or within blastocyst hatching. Located in cytosol; neuron projection; and perinuclear region of cytoplasm. Orthologous to human STMN3 (stathmin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1907.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (188794358..188802494, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (168416810..168424946, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (176808016..176816108, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Specific serine-proline phosphorylation and glycogen synthase kinase 3beta-directed subcellular targeting of stathmin 3/Sclip in neurons
Title: Specific serine-proline phosphorylation and glycogen synthase kinase 3β-directed subcellular targeting of stathmin 3/Sclip in neurons.
palmitoylation of stathmins 2 and 3 likely occurs at the Golgi and is crucial for their specific subcellular localization and trafficking
Title: Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases.
SCLIP specifically accumulates in the growing dendrites of Purkinje cells (PC)during cerebellar development and is critical for both the formation and development of PC dendritic arbors at early and late stages of postnatal dendritogenesis.
Title: SCLIP is crucial for the formation and development of the Purkinje cell dendritic arbor.
Clusterin interacts with SCLIP in PC12 cells and the interaction may act as an important modulator during neuronal differentiation.
Title: Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells.
A novel function for SCLIP in axonal morphogenesis, our results demonstrate for the first time that stathmin family proteins fulfill different and complementary roles during neuronal differentiation.
Title: The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neurons, unlike SCG10.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Stmn3 (e-PCR), detects polymorphism
- UniSTS:507249

RH128377 (e-PCR)
- UniSTS:211685

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in blastocyst hatching	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blastocyst hatching	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytoplasmic microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Rac protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rac protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of microtubule polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule polymerization or depolymerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: stathmin-3

Names: SCG10-like protein; scgn10 like-protein; stathmin-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395145.1 → NP_001382074.1 stathmin-3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q9JHU6

UniProtKB/TrEMBL

A6KM20, D3ZI49

Related

ENSRNOP00000018697.4, ENSRNOT00000018697.7

Conserved Domains (1) summary

pfam00836
Location:39 → 175

Stathmin; Stathmin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

188794358..188802494 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283198.1 → XP_063139268.1 stathmin-3 isoform X1

UniProtKB/Swiss-Prot

Q9JHU6

UniProtKB/TrEMBL

A0A0G2K8P5, A6KM21

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001395063.1: Suppressed sequence

Description

NM_001395063.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
NM_024346.2: Suppressed sequence

Description

NM_024346.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.