Epor erythropoietin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eporprovided by RGD
Official Full Name: erythropoietin receptorprovided by RGD
Primary source: RGD:2560
See related: Ensembl:ENSRNOG00000012619 AllianceGenome:RGD:2560
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables erythropoietin receptor activity. Involved in several processes, including cellular response to kainic acid; negative regulation of cell death; and negative regulation of nitric oxide biosynthetic process. Located in cytoplasm and external side of plasma membrane. Used to study high grade glioma. Biomarker of several diseases, including brain ischemia; cholangiocarcinoma; end stage renal disease; eye disease (multiple); and hepatic encephalopathy. Human ortholog(s) of this gene implicated in anemia; familial erythrocytosis 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Orthologous to human EPOR (erythropoietin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 60.4), Adrenal (RPKM 5.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (28765738..28770371, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (20489678..20494257, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (22969737..22974468, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pulpal expression of erythropoietin and erythropoietin receptor after direct pulp capping in rat.
Title: Pulpal expression of erythropoietin and erythropoietin receptor after direct pulp capping in rat.
In conclusion, this study shows that EPOR and Ngb were upregulated, and both of them act as important coordinated neuroprotectors in rh-EPO treatment of PWMD. However, the two proteins exhibit different expression patterns.
Title: Recombinant human erythropoietin offers neuroprotection through inducing endogenous erythropoietin receptor and neuroglobin in a neonatal rat model of periventricular white matter damage.
The present study aimed to determine the expression of erythropoietin (EPO) and the EPO receptor (EPOR) in spiral ganglion neurons (SGNs) in the inner ear of rats of various ages, and the associated neuronal apoptosis and hearing alterations.
Title: Age-associated expression of erythropoietin and its receptor in rat spiral ganglion neurons and its association with neuronal apoptosis and hearing alterations.
Our present findings support the hypothesis that VEGFA activates and causes an interaction between EPOR and VEGFR2 to contribute to pathological angiogenesis.
Title: VEGFA activates erythropoietin receptor and enhances VEGFR2-mediated pathological angiogenesis.
EpoR and its activity are downstream effectors of Klotho enabling it to function as a cytoprotective protein against oxidative injury.
Title: The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection.
EPO induces the expression of myelin genes in oligodendrocytes and this effect requires the presence of EPOR.
Title: Erythropoietin (EPO) increases myelin gene expression in CG4 oligodendrocyte cells through the classical EPO receptor.
11 weeks of endurance training increased erythrocyte deformability. Epo and EpoR may contribute to the decreased morphological index and deformability indicator in erythrocytes during endurance training in rats.
Title: Mechanism of endurance training-induced erythrocyte deformability in rats involves erythropoiesis.
EPOR may participate in the modulation of normal lung development. Depressed expression of EPOR and PECAM-1 may be involved in the pathogenesis of alveolar and capillary hypoplasia induced by hyperoxia.
Title: [Effects of hyperoxia on erythropoietin receptor expression in lung development of neonatal rats].
EPOR signalling in tumour cells is involved in the control of glioma growth.
Title: Targeting the erythropoietin receptor on glioma cells reduces tumour growth.
Results describe the molecular mechanisms of erythropoietin receptor regulation in neuronal cells including the role of GATA transcription factors.
Title: Erythropoietin-receptor gene regulation in neuronal cells.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141265 (e-PCR)
- UniSTS:223261

UniSTS:496753 (e-PCR)
- UniSTS:496753

Epor (e-PCR), detects polymorphism
- UniSTS:496753

UniSTS:259513 (e-PCR)
- UniSTS:259513

Epor (e-PCR), detects polymorphism
- UniSTS:259513

PMC150206P1 (e-PCR)
- UniSTS:271053

PMC150350P1 (e-PCR)
- UniSTS:271058

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables erythropoietin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables erythropoietin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables erythropoietin receptor activity	ISO Inferred from Sequence Orthology more info
enables erythropoietin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to kainic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within decidualization	ISO Inferred from Sequence Orthology more info
involved_in erythropoietin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: erythropoietin receptor

Names: EPO-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017002.2 → NP_058698.2 erythropoietin receptor precursor

See identical proteins and their annotated locations for NP_058698.2

Status: PROVISIONAL

Source sequence(s)

BC089810

UniProtKB/Swiss-Prot

Q07303

UniProtKB/TrEMBL

A6JNW6, F7EQZ7, Q5FVS4

Related

ENSRNOP00000085239.1, ENSRNOT00000115997.1

Conserved Domains (2) summary

cd00063
Location:145 → 243

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:37 → 139

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

28765738..28770371 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264889.1 → XP_063120959.1 erythropoietin receptor isoform X1

UniProtKB/Swiss-Prot

Q07303
XM_063264890.1 → XP_063120960.1 erythropoietin receptor isoform X2

UniProtKB/TrEMBL

A0A8I6GCI9
XM_063264891.1 → XP_063120961.1 erythropoietin receptor isoform X3