Tent4b terminal nucleotidyltransferase 4B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tent4bprovided by RGD
Official Full Name: terminal nucleotidyltransferase 4Bprovided by RGD
Primary source: RGD:1309587
See related: Ensembl:ENSRNOG00000024212 AllianceGenome:RGD:1309587
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Papd5
Summary: Predicted to enable guanylyltransferase activity and polynucleotide adenylyltransferase activity. Predicted to be involved in several processes, including RNA metabolic process; negative regulation of telomere maintenance via telomerase; and regulation of mRNA stability. Predicted to be located in cytoplasm. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Orthologous to human TENT4B (terminal nucleotidyltransferase 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 113.0), Heart (RPKM 112.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (34984244..35042423, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (18807616..18868969, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (19771289..19834759, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

A009S35 (e-PCR)
- UniSTS:53768

NoName (e-PCR)
- UniSTS:494730

G32820 (e-PCR)
- UniSTS:117399

UniSTS:235961 (e-PCR)
- UniSTS:235961

RH131712 (e-PCR)
- UniSTS:214995

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA 3' uridylation	ISO Inferred from Sequence Orthology more info
involved_in RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbohydrate homeostasis	ISO Inferred from Sequence Orthology more info
involved_in histone mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in miRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in poly(A)-dependent snoRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in polyadenylation-dependent ncRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyadenylation-dependent ncRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TRAMP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TRAMP complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: terminal nucleotidyltransferase 4B

Names: PAP associated domain containing 5; PAP-associated domain-containing protein 5; non-canonical poly(A) RNA polymerase PAPD5; poly(A) RNA polymerase D5, non-canonical

NP_001100886.2

EC 2.7.7.19

NP_001388155.1

EC 2.7.7.19

NP_001401942.1

EC 2.7.7.19

NP_001401944.1

EC 2.7.7.19

XP_038953651.1

EC 2.7.7.19

XP_038953652.1

EC 2.7.7.19

XP_063134086.1

EC 2.7.7.19

XP_063134087.1

EC 2.7.7.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107416.2 → NP_001100886.2 terminal nucleotidyltransferase 4B isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019
NM_001401226.1 → NP_001388155.1 terminal nucleotidyltransferase 4B isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

Related

ENSRNOP00000095048.1, ENSRNOT00000116618.1
NM_001415013.2 → NP_001401942.1 terminal nucleotidyltransferase 4B isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019
NM_001415015.2 → NP_001401944.1 terminal nucleotidyltransferase 4B isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

34984244..35042423 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097724.2 → XP_038953652.1 terminal nucleotidyltransferase 4B isoform X1

UniProtKB/TrEMBL

A0A0G2K239, A0A8I6G9A0

Related

ENSRNOP00000083622.1

Conserved Domains (1) summary

COG5260
Location:134 → 455

TRF4; DNA polymerase sigma [Replication, recombination and repair]
XM_039097723.2 → XP_038953651.1 terminal nucleotidyltransferase 4B isoform X1

UniProtKB/TrEMBL

A0A0G2K239, A0A8I6G9A0

Conserved Domains (1) summary

COG5260
Location:134 → 455

TRF4; DNA polymerase sigma [Replication, recombination and repair]
XM_063278016.1 → XP_063134086.1 terminal nucleotidyltransferase 4B isoform X2
XM_063278017.1 → XP_063134087.1 terminal nucleotidyltransferase 4B isoform X3