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    Papolb poly(A) polymerase beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304300, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Papolbprovided by RGD
    Official Full Name
    poly(A) polymerase betaprovided by RGD
    Primary source
    RGD:1310946
    See related
    AllianceGenome:RGD:1310946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in endoplasmic reticulum and nucleus. Orthologous to human PAPOLB (poly(A) polymerase beta). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See Papolb in Genome Data Viewer
    Location:
    12p11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (17157757..17160103)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (12044275..12046621)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (14112426..14114772)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene monocyte to macrophage differentiation-associated 2 Neighboring gene Rap associating with DIL domain Neighboring gene adaptor related protein complex 5 subunit zeta 1 Neighboring gene forkhead box K1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An intronless gene encoding a poly(A) polymerase is specifically expressed in testis. Lee YJ, et al. FEBS Lett, 2000 Dec 29. PMID 11150526
    2. Germ cell-specific gene 1 targets testis-specific poly(A) polymerase to the endoplasmic reticulum through protein-protein interactions. Choi HS, et al. FEBS Lett, 2008 Apr 9. PMID 18325338
    3. Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. Gruber AR, et al. Wiley Interdiscip Rev RNA, 2014 Mar-Apr. PMID 24243805, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    poly(A) polymerase beta
    Names
    poly (A) polymerase beta (testis specific)
    NP_001012020.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012020.2 → NP_001012020.1  poly(A) polymerase beta

      See identical proteins and their annotated locations for NP_001012020.1

      Status: VALIDATED

      Source sequence(s)
      BC079046, CR458765
      UniProtKB/TrEMBL
      Q6AYH1
      Conserved Domains (3) summary
      PTZ00418
      Location:10 → 569
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:367 → 508
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22 → 364
      PAP_central; Poly(A) polymerase central domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      17157757..17160103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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    Chemical Information
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    Research Materials