Fst follistatin [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Fstprovided by RGD
Full Name: follistatinprovided by RGD
Primary source: RGD:2633
See related: Ensembl:ENSRNOG00000011631 AllianceGenome:RGD:2633
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FS; FOL1; Fst-288; RATFOL1
Summary: Enables heparan sulfate proteoglycan binding activity. Predicted to be involved in hematopoietic progenitor cell differentiation; negative regulation of transcription by RNA polymerase II; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; keratinocyte proliferation; and positive regulation of hair follicle development. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 36.4), Muscle (RPKM 32.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (47856345..47863670, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (46123260..46130584, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (46537589..46544813, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage.
Title: Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage.
Follistatin expression in the central nervous system of the adult rat.
Title: Follistatin expression in the central nervous system of the adult rat.
These data suggest that ghrelin inhibits myocardial fibrosis, attenuates left ventricular remodeling, and eventually improves cardiac function by adjusting Act A/FS imbalance.
Title: Ghrelin suppresses cardiac fibrosis of post-myocardial infarction heart failure rats by adjusting the activin A-follistatin imbalance.
manifestation of polycystic ovarian syndrome-like phenotype following prenatal exposure to excess androgen is associated with irregularity in expression of the FST gene during the estrus cycle
Title: Alteration in follistatin gene expression detected in prenatally androgenized rats.
Results show that Myostatin and follistatin protein expression is reduced in the long-term hypertrophied myocardium from spontaneously hypertensive rats with heart failure.
Title: Myocardial myostatin in spontaneously hypertensive rats with heart failure.
Myogenin, myostatin, and follistatin expression is lower and myogenic regulatory factor (MRF)4 levels higher in spontaneously hypertensive rats (SHR) with heart failure compared to the Wistar-Kyoto strain.
Title: Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.
Expression of follistatin and myostatin mRNA is increased in muscle and subcutaneous fat of sedentary diabetic rats compared with sedentary control rats.
Title: Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise.
The ratio of follistatin/myostatin could be used to monitor the progress of target muscle atrophy and recovery.
Title: A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood.
Fst expression is necessary for the proliferation of small hepatocytes.
Title: Proliferation of rat small hepatocytes requires follistatin expression.
Effects of training and androgens on MYOPRO and FOLLI concentrations in blood and skeletal muscle, were investigated.
Title: Analysis of the effects of androgens and training on myostatin propeptide and follistatin concentrations in blood and skeletal muscle using highly sensitive immuno PCR.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Arb3 (e-PCR)
- UniSTS:239645

Fst (e-PCR), detects polymorphism
- UniSTS:143144

Fst (e-PCR), detects polymorphism
- UniSTS:480345

AA858520 (e-PCR)
- UniSTS:243408

D2Wox13 (e-PCR)
- UniSTS:119265

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info
enables activin binding	ISO Inferred from Sequence Orthology more info
enables activin binding	TAS Traceable Author Statement more info	PubMed
enables activin receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of ameloblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within female gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gamete generation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of follicle-stimulating hormone secretion	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: follistatin

Names: activin-binding protein; follistatin-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012561.4 → NP_036693.1 follistatin precursor

See identical proteins and their annotated locations for NP_036693.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P21674, Q80XW7

Related

ENSRNOP00000015680.1, ENSRNOT00000015680.5

Conserved Domains (2) summary

smart00274
Location:94 → 117

FOLN; Follistatin-N-terminal domain-like

smart00280
Location:117 → 164

KAZAL; Kazal type serine protease inhibitors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

47856345..47863670 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231953.5 → XP_006232015.1 follistatin isoform X1

Conserved Domains (2) summary

smart00274
Location:94 → 117

FOLN; Follistatin-N-terminal domain-like

smart00280
Location:117 → 164

KAZAL; Kazal type serine protease inhibitors
XM_006231954.5 → XP_006232016.1 follistatin isoform X2

Conserved Domains (2) summary

smart00274
Location:94 → 117

FOLN; Follistatin-N-terminal domain-like

smart00280
Location:117 → 164

KAZAL; Kazal type serine protease inhibitors