U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lias lipoic acid synthetase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305348, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Liasprovided by RGD
    Official Full Name
    lipoic acid synthetaseprovided by RGD
    Primary source
    RGD:1307270
    See related
    Ensembl:ENSRNOG00000002759 AllianceGenome:RGD:1307270
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lipoate synthase activity. Predicted to be involved in lipoate biosynthetic process. Predicted to act upstream of or within several processes, including neural tube closure; response to lipopolysaccharide; and response to oxidative stress. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 190.8), Kidney (RPKM 161.7) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lias in Genome Data Viewer
    Location:
    14p11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43230369..43247469, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42876699..42893824, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44507217..44524287, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P2 like 3 Neighboring gene small integral membrane protein 14 Neighboring gene UDP-glucose 6-dehydrogenase Neighboring gene ribosomal protein L9 Neighboring gene uncharacterized LOC134481848 Neighboring gene klotho beta

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mice with heterozygous deficiency of lipoic acid synthase have an increased sensitivity to lipopolysaccharide-induced tissue injury. Yi X, et al. J Leukoc Biol, 2009 Jan. PMID 18845616, Free PMC Article
    2. Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria. Morikawa T, et al. FEBS Lett, 2001 Jun 1. PMID 11389890
    3. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. García-García MJ, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15755804, Free PMC Article
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipoate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipoate synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipoate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lipoyl synthase, mitochondrial
    Names
    LS
    lip-syn
    lipoate synthase
    lipoic acid synthase
    NP_001012037.1
    XP_038947848.1
    XP_063129204.1
    XP_063129205.1
    XP_063129206.1
    XP_063129207.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012037.1 → NP_001012037.1  lipoyl synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001012037.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083708
      UniProtKB/Swiss-Prot
      Q5XIH4
      Related
      ENSRNOP00000003779.3, ENSRNOT00000003779.5
      Conserved Domains (1) summary
      PLN02428
      Location:41 → 369
      PLN02428; lipoic acid synthase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      43230369..43247469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273137.1 → XP_063129207.1  lipoyl synthase, mitochondrial isoform X5

    2. XM_039091920.2 → XP_038947848.1  lipoyl synthase, mitochondrial isoform X3

      Conserved Domains (1) summary
      PLN02428
      Location:41 → 326
      PLN02428; lipoic acid synthase

    3. XM_063273135.1 → XP_063129205.1  lipoyl synthase, mitochondrial isoform X2

    4. XM_063273134.1 → XP_063129204.1  lipoyl synthase, mitochondrial isoform X1

    5. XM_063273136.1 → XP_063129206.1  lipoyl synthase, mitochondrial isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIH4.1 GenPept UniProtKB/Swiss-Prot:Q5XIH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous