Dpp10 dipeptidyl peptidase like 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dpp10provided by RGD
Official Full Name: dipeptidyl peptidase like 10provided by RGD
Primary source: RGD:1306427
See related: Ensembl:ENSRNOG00000002595 AllianceGenome:RGD:1306427
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DPPY; DPP X
Summary: Predicted to enable potassium channel regulator activity and transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; protein localization to plasma membrane; and regulation of potassium ion transmembrane transport. Located in membrane. Biomarker of asthma. Human ortholog(s) of this gene implicated in asthma. Orthologous to human DPP10 (dipeptidyl peptidase like 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 210.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q11-q12

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (37145531..38821987, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (34584420..36269292, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (39430590..41173706, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show colocalization of DPP10 with Kv4 and KChIP at the plasma membrane of subthreshold A-type K+ current expressing neuron somata supports the existence of Kv4/KChIP/DPPL ternary complex in vivo
Title: Immunohistochemical localization of DPP10 in rat brain supports the existence of a Kv4/KChIP/DPPL ternary complex in neurons.
Data show that in the Kv4.2+KChIP3+DPP10 channel complex, all DPP10 variants accelerate channel gating kinetics; however, the splice variant DPP10a produces uniquely fast inactivation kinetics that accelerates with increasing depolarization.
Title: DPP10 splice variants are localized in distinct neuronal populations and act to differentially regulate the inactivation properties of Kv4-based ion channels.
DPP10 modulates Kv4.2-mediated A-type potassium channels
Title: DPP10 modulates Kv4-mediated A-type potassium channels.

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General gene information

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Markers

AU049248 (e-PCR)
- UniSTS:145696

D13Got8 (e-PCR)
- UniSTS:111655

d13rat115 (e-PCR)
- UniSTS:120882

D13Hmgc86 (e-PCR)
- UniSTS:517944

AU048090 (e-PCR)
- UniSTS:109882

AU025177 (e-PCR)
- UniSTS:115520

AU047542 (e-PCR)
- UniSTS:110406

D13RAT94 (e-PCR)
- UniSTS:120954

D13Got109 (e-PCR)
- UniSTS:115094

D13Got1 (e-PCR)
- UniSTS:111767

RH144136 (e-PCR)
- UniSTS:233382

AU048615 (e-PCR)
- UniSTS:145065

RH132186 (e-PCR)
- UniSTS:215469

AU047695 (e-PCR)
- UniSTS:110255

D13Rat148 (e-PCR), detects polymorphism
- UniSTS:226528

AU027346 (e-PCR)
- UniSTS:113398

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables dipeptidyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inactive dipeptidyl peptidase 10

Names: Kv4 potassium channel auxiliary subunit; dipeptidyl peptidase X; dipeptidylpeptidase 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012205.2 → NP_001012205.1 inactive dipeptidyl peptidase 10 isoform 3

See identical proteins and their annotated locations for NP_001012205.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q6Q629

Related

ENSRNOP00000083925.1, ENSRNOT00000112799.1

Conserved Domains (2) summary

pfam00326
Location:580 → 782

Peptidase_S9; Prolyl oligopeptidase family

pfam00930
Location:133 → 500

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
NM_001415116.1 → NP_001402045.1 inactive dipeptidyl peptidase 10 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

Q0GLB6
NM_001415117.1 → NP_001402046.1 inactive dipeptidyl peptidase 10 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

F1LPW1, Q0GLB5

Related

ENSRNOP00000084617.1, ENSRNOT00000103258.1