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    Dpp10 dipeptidyl peptidase like 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363972, updated on 6-Jun-2024

    Summary

    Official Symbol
    Dpp10provided by RGD
    Official Full Name
    dipeptidyl peptidase like 10provided by RGD
    Primary source
    RGD:1306427
    See related
    Ensembl:ENSRNOG00000002595 AllianceGenome:RGD:1306427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DPPY; DPP X
    Summary
    Predicted to enable potassium channel regulator activity and transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; protein localization to plasma membrane; and regulation of potassium ion transmembrane transport. Located in membrane. Biomarker of asthma. Human ortholog(s) of this gene implicated in asthma. Orthologous to human DPP10 (dipeptidyl peptidase like 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 210.9) See more
    Orthologs
    NEW
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    Genomic context

    See Dpp10 in Genome Data Viewer
    Location:
    13q11-q12
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (37145531..38821987, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (34584420..36269292, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (39430590..41173706, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene tubulin-specific chaperone A-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein L23a, pseudogene 18 Neighboring gene uncharacterized LOC108352624 Neighboring gene uncharacterized LOC134481485 Neighboring gene uncharacterized LOC120096236 Neighboring gene uncharacterized LOC102554127

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables dipeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inactive dipeptidyl peptidase 10
    Names
    Kv4 potassium channel auxiliary subunit
    dipeptidyl peptidase X
    dipeptidylpeptidase 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012205.2NP_001012205.1  inactive dipeptidyl peptidase 10 isoform 3

      See identical proteins and their annotated locations for NP_001012205.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q6Q629
      Related
      ENSRNOP00000083925.1, ENSRNOT00000112799.1
      Conserved Domains (2) summary
      pfam00326
      Location:580782
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:133500
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    2. NM_001415116.1NP_001402045.1  inactive dipeptidyl peptidase 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      Q0GLB6
    3. NM_001415117.1NP_001402046.1  inactive dipeptidyl peptidase 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F1LPW1, Q0GLB5
      Related
      ENSRNOP00000084617.1, ENSRNOT00000103258.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      37145531..38821987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272512.1XP_063128582.1  inactive dipeptidyl peptidase 10 isoform X1

      UniProtKB/TrEMBL
      F1LPW1