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    RET3 coatomer subunit zeta [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856097, updated on 17-May-2024

    Summary

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    Gene symbol
    RET3
    Gene description
    coatomer subunit zeta
    Primary source
    FungiDB:YPL010W
    Locus tag
    YPL010W
    See related
    SGD:S000005931; AllianceGenome:SGD:S000005931; VEuPathDB:YPL010W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Part of COPI vesicle coat. Orthologous to several human genes including COPZ1 (COPI coat complex subunit zeta 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RET3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (535018..535587)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mRNA-binding protein RRP12 Neighboring gene Taf3p Neighboring gene Rqc2p Neighboring gene DNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and functional characterization of yeast zeta-COP. Yamazaki S, et al. J Biochem, 1997 Jan. PMID 9058184
    2. Full-length structural model of RET3 and SEC21 in COPI: identification of binding sites on the appendage for accessory protein recruitment motifs. Alisaraie L, et al. J Mol Model, 2012 Jul. PMID 22246286, Free PMC Article
    3. Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval. Cosson P, et al. EMBO J, 1996 Apr 15. PMID 8617224, Free PMC Article
    4. Molecular structure and flexibility of the yeast coatomer as revealed by electron microscopy. Yip CK, et al. J Mol Biol, 2011 May 20. PMID 21435344, Free PMC Article
    5. Alpha-COP can discriminate between distinct, functional di-lysine signals in vitro and regulates access into retrograde transport. Schröder-Köhne S, et al. J Cell Sci, 1998 Dec. PMID 9811561

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COPI vesicle coat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in COPI-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit zeta
    NP_015315.1
    • Zeta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      535018..535587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183824.1 → NP_015315.1  TPA: coatomer subunit zeta [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015315.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W402, P53600
      UniProtKB/TrEMBL
      A0A6A5Q2E7, A6ZWN6, B3LL52, B5VTF2, C7GU40, C8ZJ17, G2WPH0, N1NVI8
      Conserved Domains (1) summary
      COG5541
      Location:3 → 189
      RET3; Vesicle coat complex COPI, zeta subunit [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53600.1

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