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    SEC16 Sec16p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856020, updated on 17-May-2024

    Summary

    Gene symbol
    SEC16
    Gene description
    Sec16p
    Primary source
    FungiDB:YPL085W
    Locus tag
    YPL085W
    See related
    SGD:S000006006; AllianceGenome:SGD:S000006006; VEuPathDB:YPL085W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LPF1
    Summary
    Enables protein-membrane adaptor activity. Involved in COPII vesicle coating; macroautophagy; and protein localization to endoplasmic reticulum exit site. Located in ER to Golgi transport vesicle membrane and endoplasmic reticulum exit site. Orthologous to several human genes including SEC16A (SEC16 homolog A, endoplasmic reticulum export factor). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See SEC16 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (387067..393654)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene alkaline dihydroceramidase Neighboring gene Elongator subunit ELP3 Neighboring gene Bro1p Neighboring gene tRNA splicing endonuclease subunit SEN54

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in COPII vesicle coating IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in COPII vesicle coating IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to endoplasmic reticulum exit site IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ER to Golgi transport vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum exit site IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Sec16p
    NP_015240.1
    • COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      387067..393654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183899.1NP_015240.1  TPA: Sec16p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015240.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3T2, P48415, Q02822
      UniProtKB/TrEMBL
      A0A8H4BU54, A6ZWG6
      Conserved Domains (4) summary
      PHA03247
      Location:680980
      PHA03247; large tegument protein UL36; Provisional
      pfam12935
      Location:291567
      Sec16_N; Vesicle coat trafficking protein Sec16 N-terminus
      pfam12931
      Location:11361420
      Sec16_C; Sec23-binding domain of Sec16
      pfam12932
      Location:9941093
      Sec16; Vesicle coat trafficking protein Sec16 mid-region