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    EEB1 medium-chain fatty acid ethyl ester synthase/esterase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856010, updated on 17-May-2024

    Summary

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    Gene symbol
    EEB1
    Gene description
    medium-chain fatty acid ethyl ester synthase/esterase
    Primary source
    FungiDB:YPL095C
    Locus tag
    YPL095C
    See related
    SGD:S000006016; AllianceGenome:SGD:S000006016; VEuPathDB:YPL095C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alcohol O-octanoyltransferase activity and short-chain carboxylesterase activity. Involved in medium-chain fatty acid biosynthetic process and medium-chain fatty acid catabolic process. Orthologous to human ABHD1 (abhydrolase domain containing 1) and ABHD3 (abhydrolase domain containing 3, phospholipase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EEB1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (368071..369441, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Eri1p Neighboring gene peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase Neighboring gene Sec63 complex subunit SEC62 Neighboring gene putative GTPase NOG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Downregulation of EHT1 and EEB1 in Saccharomyces cerevisiae Alters the Ester Profile of Wine during Fermentation. Yang X, et al. J Microbiol Biotechnol, 2022 Jun 28. PMID 35484971, Free PMC Article
    2. Controlled intracellular trafficking alleviates an expression bottleneck in S. cerevisiae ester biosynthesis. Zhu J, et al. Metab Eng Commun, 2019 Jun. PMID 30622894, Free PMC Article
    3. Parameters affecting ethyl ester production by Saccharomyces cerevisiae during fermentation. Saerens SM, et al. Appl Environ Microbiol, 2008 Jan. PMID 17993562, Free PMC Article
    4. The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. Saerens SM, et al. J Biol Chem, 2006 Feb 17. PMID 16361250
    5. Differential Analysis of Proteins Involved in Ester Metabolism in two Saccharomyces cerevisiae Strains during the Second Fermentation in Sparkling Wine Elaboration. González-Jiménez MDC, et al. Microorganisms, 2020 Mar 13. PMID 32183073, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of EHT1 and EEB1 in Saccharomyces cerevisiae Alters the Ester Profile of Wine during Fermentation.
      Title: Downregulation of EHT1 and EEB1 in Saccharomyces cerevisiae Alters the Ester Profile of Wine during Fermentation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acetylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol O-octanoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables short-chain carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in medium-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in medium-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in medium-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    medium-chain fatty acid ethyl ester synthase/esterase
    NP_015230.1
    • Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      368071..369441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183909.1 → NP_015230.1  TPA: medium-chain fatty acid ethyl ester synthase/esterase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015230.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3S2, Q02891
      UniProtKB/TrEMBL
      A0A8H4BTU1, C7GJ49, G2WP86, N1NVX0
      Conserved Domains (1) summary
      COG0429
      Location:38 → 456
      YheT; Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02891.1

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