Larp6 La ribonucleoprotein 6, translational regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Larp6provided by MGI
Official Full Name: La ribonucleoprotein 6, translational regulatorprovided by MGI
Primary source: MGI:MGI:1914807
See related: Ensembl:ENSMUSG00000034839 AllianceGenome:MGI:1914807
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Achn; 5430431G03Rik
Summary: Predicted to enable RNA binding activity and myosin binding activity. Predicted to be involved in positive regulation of collagen biosynthetic process; positive regulation of mRNA binding activity; and positive regulation of translation. Predicted to act upstream of or within regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of polysome. Predicted to be active in nucleus. Is expressed in brain; dorsal root ganglion; facial ganglion; and trigeminal ganglion. Orthologous to human LARP6 (La ribonucleoprotein 6, translational regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 12.1), cortex adult (RPKM 9.2) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 32.87 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (60620404..60646084)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (60713121..60738801)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that insulin-like growth factor 1 (IGF1) could promote collagen I alpha 2 (COL1A2) expression and osteoblast differentiation in primary pre-osteoblasts by increasing La ribonucleoprotein domain family member 6 (Larp6) expression via a posttranscriptional mechanism.
Title: Insulin-like growth factor-1 promotes osteogenic differentiation and collagen I alpha 2 synthesis via induction of mRNA-binding protein LARP6 expression.
LARP6 is a critical mediator by which IGF-1 augments synthesis of collagen type I in vascular smooth muscle
Title: Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA.
Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
Title: Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
Achn enhances human breast tumor growth and vascularization and that this activity is dependent on nuclear localization.
Title: The novel lupus antigen related protein acheron enhances the development of human breast cancer.
achn plays key roles in the processes of differentiation and self-renewal
Title: Regulation of muscle differentiation and survival by Acheron.
These data define Achn as a newly discovered regulatory molecule that presumably mediates a variety of developmental and homeostatic processes in animals.
Title: Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Larp6 (e-PCR), detects polymorphism
- UniSTS:479006

AI552438 (e-PCR)
- UniSTS:164405

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA stem-loop binding	ISO Inferred from Sequence Orthology more info
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: la-related protein 6

Names: La ribonucleoprotein domain family, member 6; acheron

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026235.4 → NP_080511.2 la-related protein 6

See identical proteins and their annotated locations for NP_080511.2

Status: PROVISIONAL

Source sequence(s)

AC156940

Consensus CDS

CCDS23258.1

UniProtKB/Swiss-Prot

Q8BN59, Q8C9A3, Q8CA51, Q9CTN3, Q9D3J0

Related

ENSMUSP00000040309.6, ENSMUST00000038407.6

Conserved Domains (3) summary

cd08033
Location:93 → 169

LARP_6; La RNA-binding domain of La-related protein 6

cd12289
Location:184 → 292

RRM_LARP6; RNA recognition motif in La-related protein 6 (LARP6) and similar proteins

pfam12901
Location:468 → 482

SUZ-C; SUZ-C motif