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    Pigg phosphatidylinositol glycan anchor biosynthesis, class G [ Mus musculus (house mouse) ]

    Gene ID: 433931, updated on 2-May-2024

    Summary

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    Official Symbol
    Piggprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Gprovided by MGI
    Primary source
    MGI:MGI:3576484
    See related
    Ensembl:ENSMUSG00000029263 AllianceGenome:MGI:3576484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpi7
    Summary
    Predicted to enable CP2 mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human PIGG (phosphatidylinositol glycan anchor biosynthesis class G). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 5.9), genital fat pad adult (RPKM 4.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pigg in Genome Data Viewer
    Location:
    5 F; 5 52.9 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108460679..108497225)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108312813..108349359)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 18 Neighboring gene predicted gene 8190 Neighboring gene STARR-seq mESC enhancer starr_13907 Neighboring gene predicted gene, 54303 Neighboring gene down-regulator of transcription 1 Neighboring gene RIKEN cDNA 9330198I05 gene Neighboring gene transmembrane 217, retrotransposed

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. Shishioh N, et al. J Biol Chem, 2005 Mar 11. PMID 15632136
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CP2 mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CP2 mannose-ethanolamine phosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GPI ethanolamine phosphate transferase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081234.3 → NP_001074703.1  GPI ethanolamine phosphate transferase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC124107
      Consensus CDS
      CCDS39203.1
      UniProtKB/TrEMBL
      D3YTQ6, D3Z4I0
      Related
      ENSMUSP00000031189.8, ENSMUST00000031189.14
      Conserved Domains (2) summary
      COG0841
      Location:676 → 733
      AcrB; Multidrug efflux pump subunit AcrB [Defense mechanisms]
      cd16024
      Location:62 → 335
      GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G

    2. NM_001310689.2 → NP_001297618.1  GPI ethanolamine phosphate transferase 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC124107
      Consensus CDS
      CCDS80354.1
      UniProtKB/TrEMBL
      D3YTQ6, D3Z3Y1
      Related
      ENSMUSP00000113818.2, ENSMUST00000119014.8
      Conserved Domains (1) summary
      cd16024
      Location:62 → 335
      GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G

    3. NM_001370998.1 → NP_001357927.1  GPI ethanolamine phosphate transferase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124107
      UniProtKB/TrEMBL
      D3YTQ6
      Conserved Domains (1) summary
      cd16024
      Location:62 → 335
      GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G

    RNA

    1. NR_163827.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124107

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108460679..108497225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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