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    Oas1f 2 ' -5 ' oligoadenylate synthetase 1F [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494199, updated on 30-Mar-2024

    Summary

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    Symbol
    Oas1fprovided by RGD
    Full Name
    2 ' -5 ' oligoadenylate synthetase 1Fprovided by RGD
    Primary source
    RGD:1359647
    See related
    Ensembl:ENSRNOG00000068922 AllianceGenome:RGD:1359647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Predicted to be involved in defense response to virus and innate immune response. Predicted to be located in cytoplasm. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Uterus (RPKM 9.9), Lung (RPKM 9.1) and 9 other tissues See more
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    Genomic context

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    See Oas1f in Genome Data Viewer
    Location:
    12q16
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41357647..41367123, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35697024..35706617, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41227910..41237209, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 1A Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1H Neighboring gene 2-5 oligoadenylate synthetase 1B Neighboring gene 2'-5' oligoadenylate synthetase 1E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2 ' -5 ' oligoadenylate synthetase 1F
    Names
    2'-5' oligoadenylate synthetase 1F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009490.2 → NP_001009490.1  2 ' -5 ' oligoadenylate synthetase 1F

      See identical proteins and their annotated locations for NP_001009490.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      Q5MYW8
      Related
      ENSRNOP00000070360.1, ENSRNOT00000088023.2
      Conserved Domains (2) summary
      cd05400
      Location:26 → 152
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:160 → 347
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      41357647..41367123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089660.2 → XP_038945588.1  2 ' -5 ' oligoadenylate synthetase 1F isoform X2

      Conserved Domains (1) summary
      pfam10421
      Location:60 → 191
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    2. XM_039089659.2 → XP_038945587.1  2 ' -5 ' oligoadenylate synthetase 1F isoform X1

      Conserved Domains (1) summary
      pfam10421
      Location:31 → 220
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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